Review Article

Heart Rate and Cardiovascular Disease: An Alternative to Beta Blockers

Figure 1

(a) a diagram demonstrates If current and other ionic currents in phase 4 of action potential. For simplicity 𝐼 c a L and 𝐼 c a T are shown together as 𝐼 c a . (b) Inhibition of 𝐼 𝑓 phase 4 of action potential leads to reduction of slope from a to b. This results in prolonged phase 4 or firing frequency of action potential, thus slower heart rate.
179350.fig.001a
(a)
179350.fig.001b
(b)