Clinical Study

Pretest Score for Predicting Microbubble Contrast Agent Use in Stress Echocardiography: A Method to Increase Efficiency in the Echo Laboratory

Table 2

Significant predictors of contrast agent use included in the final score model and the allocated score values.

PredictorUnivariate analysisMultivariate analysisAllocated score
𝛽 Coefficient 𝑃 valueOR (95% CI) 𝛽 Coefficient 𝑃 valueOR (95% CI)

Age ≥65 𝑦 0.38 < .0011.46 (1.35–1.57)0.28 < .0011.32 (1.21–1.44)1
Male sex0.21 < .0011.23 (1.14–1.32)0.21 < .0011.23 (1.13–1.34)1
Smoking0.25 < .0011.29 (1.2–1.39)0.12.0031.13 (1.04–1.23)1
Multiple ( > 2) risk factors for C A D 0.5 < .0011.65 (1.53–1.79)0.13.0051.13 (1.04–1.24)1
B M I
< 250
25–300.57 < .0011.76 (1.57–1.98)1
> 30–351.33 < .0013.79 (3.35–.26)2
> 35–401.78 < .0015.94 (5.11–6.90)3
> 402.12 < .0018.36 (6.92–10.09)4
Dobutamine stress e c h o c a r d i o g r a p h y x 0.96 < .0012.62 (2.43–2.83)0.76 < .0012.13 (1.96–2.32)1
Previous history of C A D / / 0.49 < .0011.63 (1.50–1.78)0.31 < .0011.36 (1.23–1.50)1
Abnormal E C G { 0.28 < .0011.32 (1.23–1.43)0.11.011.11 (1.03–1.21)1

BMI, body mass index; CAD, coronary artery disease; CI, confidence interval; ECG, electrocardiogram; OR, odds ratio. R i s k factors include hypertension, diabetes, hyperlipidemia, and family history of CAD. E l l i p s e s indicate not applicable. R e f e r e n c e category is a BMI lower than 25. x R e s u l t s of dobutamine stress echocardiography compared with results of treadmill stress echocardiography. / / I n c l u d e s prior myocardial infarction and prior percutaneous coronary intervention or coronary artery bypass graft. { I n c l u d e s those showing left ventricular hypertrophy, pathologic Q waves, left bundle branch block, or resting ST-T wave abnormalities.