Two-Photon Laser Scanning Microscopy of the Transverse-Axial Tubule System in Ventricular Cardiomyocytes from Failing and Non-Failing Human Hearts

Figure 4

Volume and Surface Dimensions of the Transverse-Axial Tubule System. TATS volume (“V_TATS”, (a)), TATS surface area (“A_TATS”, (b)) and total cell membrane area (“A_Memb”, (c)) are shown to be normalized to cell volume (“V_Cell”). Also, TATS surface area is shown as the proportion to total cell membrane area (d). The results are given for all myocytes analyzed from non-failing (open symbols, 𝑛=10, 2 hearts) and failing hearts (closed symbols, 𝑛=15, 4 hearts). Different symbols denote different cell batches. Bar symbols in the middle of each chart indicate the mean values ± SEM. Calculated 𝑃-values as given.

(a)

(b)

(c)

(d)