Two-Photon Laser Scanning Microscopy of the Transverse-Axial Tubule System in Ventricular Cardiomyocytes from Failing and Non-Failing Human Hearts
Table 2
Volume and Surface Area Dimensions of the Transverse-Axial Tubule System. Fractions were calculated individually for all cells before averaging. Regions containing the cell's nucleus or autofluorescent beads within the images were excluded before quantitative analysis.
Unit
Non-failing
Failing
[%]
8.67 ± 0.62
7.93 ± 0.64
[m²/m³]
0.403 ± 0.026
0.343 ± 0.020
[m²/m³]
0.327 ± 0.033
0.290 ± 0.028
[m²/m³]
0.729 ± 0.042
0.632 ± 0.041
[m²/m³]
4.682 ± 0.123
4.476 ± 0.197
[%]
55.68 ± 2.63
54.89 ± 2.12
Apparent cellular volume, that is, volume surrounded by the exterior cellular membrane
Intracellular volume occupied by the TATS
Surface area of the TATS
Surface of the exterior cellular membrane
Total membrane surface area, that is,
previous studies ratio is referred to as fractional volume, TATS volume fraction, or t index.