Research Needed to Support Clinical Use of Biomarkers as Prognostic Indicators for Patients with Heart Failure

Figure 1

ROC curves. Sensitivity versus 1 minus specificity for discriminating subjects who did or did not die within 1 year based on all possible cut points of predicted probabilities derived from a prediction model that included several baseline clinical assessments (Clinical model) and the same model plus two biomarkers, BNP and hs-TnT. The circles on each curve correspond to the cut point of interest in this example, that is those with a ≥10% predicted probability of dying within 1 year.