Research Needed to Support Clinical Use of Biomarkers as Prognostic Indicators for Patients with Heart Failure

Table 1

Reclassification of Subjects into Prognostic Groups by Adding Two Biomarkers, BNP and hs-TnT, to a Prediction Model Based on Other Baseline Assessments.

Model 1: Baseline Assessments	Model 2: Baseline Assessments+Biomarkers
	Predicted Probability <10%	Predicted Probability≥10%	Total
Predicted Probability <10%
Number of subjects	2003 (85%)^∗	342 (15%)	2345
Observed Dead	4.4%	12.3%	5.6%
Predicted Dead Model 1	5.7%	7.8%	6.0%
Predicted Probability ≥10%
Number of subjects	345 (29%)	861(71%)	1206
Observed Dead	7.2%	20.3%	16.6%
Predicted Dead Model 1	13.0%	16.9%	15.8%
Total
Number of subjects	2348 (66%)	1203 (34%)	3551
Observed Dead	4.9%	18.0%	9.3%
Predicted Dead Model 2	5.0%	17.8%

^∗Percentages in parentheses are calculated across each row.