Additive Value of B-Type Natriuretic Peptide on Rest ²⁰¹Tl-Dipyridamole Stress ^99mTc-Sestamibi Gated Myocardial SPECT in Patients with Normal Left Ventricular Systolic Function

Table 1

Baseline characteristics according to the SPECT results.

	(+) SPECT			(−) SPECT
	TP	FP	𝑃	TN	FN	𝑃
Patients, n (%)	94 (61.8)	48 (38.2)		55 (67.1)	27 (32.9)
Gender, n (M/F)	59/35	23/25	.09	36/19	18/9	.91
Age, years	64.2±9.0	59.9±9.6	.007**	61.0±10.2	64.9±8.0	.14
BMI, kg/m2	24.8±2.6	26.2±3.8	.07	24.8±2.6	25.2±3.1	.66
Severity of coronary artery disease
Insignificant, n (%)	0 (0)	48 (100)		55 (100)	0 (0)
1 VD, n (%)	38 (40.4)	0 (0)		0 (0)	13 (48.1)
MVD, n (%)	56 (59.6)	0 (0)		0 (0)	14 (51.9)
Medical history
DM, n (%)	42 (44.7)	15 (31.2)	0.12	8 (14.5)	10 (37.0)	.02*
HTN, n (%)	73 (77.7)	29 (60.4)	0.03*	27 (49.0)	20 (74.1)	.03*
Dyslipidemia, n (%)	44 (46.8)	23 (47.9)	0.90	22 (40.0)	12 (44.4)	.70
Smoker, n (%)	38 (40.4)	14 (29.1)	0.16	23 (41.8)	9 (33.3)	.72
Laboratory results
Total-C, mg/dL	176.3±37.2	177.1±35.0	.77	177.2±34.8	177.7±41.9	.96
LDL-C, mg/dL	107.4±32.9	107.9±28.5	.64	105.3±31.9	107.9±36.3	.88
HDL-C, mg/dL	42.3±10.2	46.0±10.1	.43	46.1±12.1	43.6±10.6	.01*
hs-CRP, mg/dL	0.50±1.03	0.35±0.57	.39	0.20±0.32	0.38±0.44	.73
CCr, mL/min	66.7±16.8	76.3±21.0	.47	71.3±16.5	67.2±15.1	.01
BNP, pg/mL^¶	38.5	19.0	.01*	22.0	39.0	.002**
	(19.0–79.8)	(9.3–35.8)		(15.0–43.0)	(23.0–77.0)
Echocardiographic data
LV EF, %	63±5	62± 6	.49	62±6	64±6	.54
LA, mm	39.1±4.7	38.4±4.9	.80	39.3±4.4	39.0±4.2	.90
E, m/s	0.60±0.15	0.60±0.15	.31	0.59±0.16	0.64±0.17	.28
A, m/s	0.76±0.18	0.70±0.18	.36	0.70±0.22	0.76±0.27	.30
E/A ratio	0.83±0.27	0.89±0.33	.35	0.90±0.31	0.92±0.31	.43
DT, ms	224.4±61.9	214.1±44.0	.85	232.0±61.2	241.8±44.7	.78
SPECT data
LV EF, %	65.2±7.1	66.0±7.9	.69	67.8±7.9	66.1±6.7	.71
LVEDV, mL	85.7±25.4	82.1±20.4	.46	83.8±23.0	82.9±24.0	.12
LVESV, mL	30.9±13.8	28.7±11.5	.48	28.0±12.4	28.8±12.0	.49
SRS	1.032±2.72	0.44±0.92	.46	0.22±0.65	0.18±0.73	.47
SSS	8.47±5.61	2.53±2.53	<.001***	2.37±3.01	2.15±2.31	.45
SDS	7.42±4.64	3.27±2.52	<.001***	2.15±2.78	1.97±2.08	.47

* 𝑃<.05; **𝑃<.01; ***𝑃<.001
TP: true positive; FP: false positive; TN: true negative; FN: false negative; BMI: Body mass index, calculated as weight (kg) divided by square height (m²); VD: vessel disease; MVD: multi-vessel disease; Total C: total cholesterol; LDL-C: Low-density lipoprotein Cholesterol; HDL-C: High density lipoprotein Cholesterol; CCr: Creatinine clearance rate in milliliters per minute was calculated from the Cockcroft and Gault equation: ((140-age) × weight (kg)/serum creatinine (mmol/L)), multiplied by a constant of 1.25 in men and 1.03 in women; LV EF: Left ventricular Ejection fraction; LA: Left atrium; E: mitral peak early diastolic velocity; A: mitral peak late diastolic velocity; DT: E -wave deceleration time; LVEDV: left ventricular end-diastolic volume; LVESV: left ventricular end-systolic volume; SSS: summed stress score; SRS: summed rest score; SDS: summed difference score.
^†Current or ex-smoker.
^¶expressed as median (interpercentile).