Beta-Blocker Therapy and Hemophagocytic Lymphohistiocytosis: A Case Report

Table 1

Parameter	Normal Value	Baseline	SIRS I	SIRS II	Discharge	SIRS III
Timeframe (days)			3	4	2	18
Age (weeks)			23	24	27	29
Cardiovascular changes
Heart rate (1/min)		130	110	100	100	150
Fractional shortening (%)		45	45	32	59	36
LV Pressure (mmHg)§		101	79	79	71	63
Mean arterial pressure (mmHg)		86	65	74	60	50
Pulmonary artery pressuresys (mmHg)#		63	61	48	30	40
Hepatic changes
GOTmax (U/l)	0–35	319	28839	3778	107	323
LDHmax (E/l)	0–250		220000	9097	530	2753
Bilirubinmax (mmol/l)	0.4–1.2		2.8	9.51	6.16	7.06
Renal changes
Creatininemax (mg/dl)	0.70–1.20	0.45	0.62	1.94	0.67	1.57
Ureamax (mg/dl)	11–55		75	133	122	210
Coagulation
Thrombocytemin (1000/l)	140000–400000	690000	153000	88000	61000	58000
INRmax (Ratio)	0.8–1.25		2.11	3.24	1.34	1.47
Inflammatory markers
White blood cellmax (1000/l)	3.6–10.0	16.7	28.280	16.999	12.800	3.690
Normoblast absolute (1000/l)	None	0	22.220	2.101	0	16.810
Procalcitoninmax (pg/ml)	0.1–0.5	5.61	13.67	85.78	2.9	420
sCD25 (U/ml)∗	<1000	2220	2160			3916
TNF-𝛼 (pg/ml)∗	<3	90.4	104.8			98.4
IL-8 (pg/ml)∗	<3	152	346			328
IL-6 (pg/ml)∗	<6	72	108			55.6
IL-1𝛽 (pg/ml)∗	<5	2.9	4.0			1.68
hs CRPmax (mg/dl)	<1.0	0.00	0.21	0.83	0.21	0.00
NT-Pro-BNP (pg/ml)	0–85		6374	31127	31689	71485
Ferritin (𝜇g/l)∗	20–400	33016	27516	94099	419	3676
Triglyceride (mg/dl)	35–180			1349	222	327
Serum Calciummin (mmol/l)	2.15–2.75	1.81	2.23	1.61	2.54	2.05

∗: measurements from stored plasma
§: left ventricular pressure estimated from Doppler measurements of mitral valve regurgitant jet velocity
#: systolic pulmonary artery pressure estimated using Doppler measurements across pulmonary artery band:
Pulmonary artery pressuresys = LV pressure – PAB gradient.