Case Report
Beta-Blocker Therapy and Hemophagocytic Lymphohistiocytosis: A Case Report
| Parameter | Normal Value | Baseline | SIRS I | SIRS II | Discharge | SIRS III |
| Timeframe (days) | | | 3 | 4 | 2 | 18 | Age (weeks) | | | 23 | 24 | 27 | 29 |
| Cardiovascular changes | | | | | | | Heart rate (1/min) | | 130 | 110 | 100 | 100 | 150 | Fractional shortening (%) | | 45 | 45 | 32 | 59 | 36 | LV Pressure (mmHg) | | 101 | 79 | 79 | 71 | 63 | Mean arterial pressure (mmHg) | | 86 | 65 | 74 | 60 | 50 | Pulmonary artery pressure (mmHg) | | 63 | 61 | 48 | 30 | 40 |
| Hepatic changes | | | | | | | GOT (U/l) | 0–35 | 319 | 28839 | 3778 | 107 | 323 | LDH (E/l) | 0–250 | | 220000 | 9097 | 530 | 2753 | Bilirubin (mmol/l) | 0.4–1.2 | | 2.8 | 9.51 | 6.16 | 7.06 |
| Renal changes | | | | | | | Creatinine (mg/dl) | 0.70–1.20 | 0.45 | 0.62 | 1.94 | 0.67 | 1.57 | Urea (mg/dl) | 11–55 | | 75 | 133 | 122 | 210 |
| Coagulation | | | | | | | Thrombocyte (1000/l) | 140000–400000 | 690000 | 153000 | 88000 | 61000 | 58000 | INR (Ratio) | 0.8–1.25 | | 2.11 | 3.24 | 1.34 | 1.47 |
| Inflammatory markers | | | | | | | White blood cell (1000/l) | 3.6–10.0 | 16.7 | 28.280 | 16.999 | 12.800 | 3.690 | Normoblast absolute (1000/l) | None | 0 | 22.220 | 2.101 | 0 | 16.810 | Procalcitonin (pg/ml) | 0.1–0.5 | 5.61 | 13.67 | 85.78 | 2.9 | 420 | sCD25 (U/ml) | 1000 | 2220 | 2160 | | | 3916 | TNF- (pg/ml) | 3 | 90.4 | 104.8 | | | 98.4 | IL-8 (pg/ml) | 3 | 152 | 346 | | | 328 | IL-6 (pg/ml) | 6 | 72 | 108 | | | 55.6 | IL-1 (pg/ml) | 5 | 2.9 | 4.0 | | | 1.68 | hs CRP (mg/dl) | 1.0 | 0.00 | 0.21 | 0.83 | 0.21 | 0.00 | NT-Pro-BNP (pg/ml) | 0–85 | | 6374 | 31127 | 31689 | 71485 | Ferritin (g/l) | 20–400 | 33016 | 27516 | 94099 | 419 | 3676 | Triglyceride (mg/dl) | 35–180 | | | 1349 | 222 | 327 | Serum Calcium (mmol/l) | 2.15–2.75 | 1.81 | 2.23 | 1.61 | 2.54 | 2.05 |
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: measurements from stored plasma : left ventricular pressure estimated from Doppler measurements of mitral valve regurgitant jet velocity : systolic pulmonary artery pressure estimated using Doppler measurements across pulmonary artery band: Pulmonary artery pressure = LV pressure – PAB gradient.
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