Review Article
Cardiovascular Effects in Childhood Cancer Survivors Treated with Anthracyclines
Table 1
Characteristics and course of anthracycline-induced cardiotoxicity [
15].
| Characteristics | Acute cardiotoxicity | Early-onset, chronic progressive cardiotoxicity | Late-onset, chronic progressive cardiotoxicity |
| Onset | Within the first week of anthracycline treatment | <1 year after the completion of anthracycline treatment | ≥1 year after the completion of anthracycline treatment | Risk factor dependence | Unknown | Yesa | Yesa | Clinical features in adults | Transient depression of myocardial contractility | Dilated cardiomyopathy | Dilated cardiomyopathy | Clinical features in children | Transient depression of myocardial contractility | Restrictive cardiomyopathy and/or dilated cardiomyopathy | Restrictive cardiomyopathy and/or dilated cardiomyopathy | Course | Usually reversible on discontinuation of anthracycline | Can be progressive | Can be progressive |
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From Adams et al. [15]. Reprinted with permission from John Wiley & Sons, Inc.
aData from Giantris et al. [16], and Grenier and Lipshultz [17].
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