Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome
Figure 2
Cardiorenal immunohistochemistry of TGF-β1. TGF-β1-stained spots are observed in the myocardium (upper panels) and coronary artery (middle panels) in Ang II-infused wild-type mice (upper and middle panels). Macroscopic renal injury and TGF-β1-stained renal glomerulus are found in Ang II-infused mice, especially eNOS-/- mice (lower panels). Pitavastatin treatment attenuates cardiorenal TGF-β1 expression in Ang II-infused mice. Modified from the article by Yagi et al. [37].