Does Smoking Act as a Friend or Enemy of Blood Pressure? Let Release Pandora's Box

Table 3

Common classes of antihypertensive drugs and their response to smoking.

Drug	Mechanism of action	Response to smoking
Beta-blockers	Inhibition beta 1 receptors	Highly reduced (+++)
ACE-Inhibitors	Blocked conversion Angiotensin 1 to Angiotensin II	Highly reduced (+++)
Calcium Antagonists	Block entry of calcium into vascular smooth cells	Reduced (++/−)
Diuretics	Decreased body sodium and extracellular fluid volume	Highly reduced (+++)
Angiotensin receptor blockers	Block AT1 receptor	not yet known (− −/+ ?)

+++ : strongest reduction
++/− :  moderate reduction
+ :  mild reduction
− −/+  :  increase
?  : not yet established.