MicroRNA Expression Profile in CAD Patients and the Impact of ACEI/ARB

Figure 3

Medications influence the circulating levels of specific miRNAs. Expression data obtained from the patients (angiographically significant CAD or ≥2 CAD risk factors but no significant CAD lesions) on ACEI or ARB compared to similar patients not on ACEI or ARB. Circulating levels of miR-155, miR-19a, miR-378, miR-222, miR-342, miR-145, and miR-30e-5p were decreased in patients who were taking these medications. P values: miR-155 =  .0007, miR-19a =  .035, miR-29a = NS, miR-30e-5p =  .011, miR-145 =  .003, miR-181d = NS, miR-222 =  .002, miR-342 =  .0036, and miR-378 =  .0004.