Right Ventricular Dysfunction and Failure in Chronic Pressure Overload

Figure 2

Example of ventricular-vascular coupling analysis. Systolic portions of the RV pressure-volume curves showing end-systolic elastance (Ees) and arterial elastance (Ea) lines. Ventricular-vascular coupling (Ees/Ea) is improved with prostacyclin due to a decrease in arterial elastance (Ea) in a dog with acute RV failure induced by transient pulmonary artery constriction. (a) Prior to prostacyclin infusion. (b) After prostacyclin infusion. (c) Ventricular-vascular coupling efficiency (Ees/Ea) at baseline, during pulmonary artery constriction (Constr.), after pulmonary artery release, and during prostacyclin infusion at 2 doses (𝑛=7; values are means + standard error). ^#𝑃<0.05 compared with baseline; ^§𝑃<0.05 compared with release, adapted from [27].

(a)

(b)

(c)