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Cardiology Research and Practice
Volume 2011, Article ID 578390, 6 pages
Case Report

Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review

1Aintree Cardiac Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
2Department of Pathology, The Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK

Received 12 November 2010; Revised 24 December 2010; Accepted 7 January 2011

Academic Editor: Jalal K. Ghali

Copyright © 2011 Reza Ashrafi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. We present the case of a 35-year-old gentleman who presented with an aggressive cardiomyopathy with normal coronary arteries. He was later diagnosed with systemic lupus-related cardiomyopathy. Methods. We undertook an extensive review of the literature regarding cardiac manifestations of lupus and used over 100 journals to identify the key points in pathology, diagnosis, and treatment. Results. We have shown that cardiac lupus can be rapidly progressive and, unless treated early, can have severe consequences. The predominant pathologies are immune complex and accelerated atherosclerosis drive. Treatment comprised of high-level immunosuppression.