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Cardiology Research and Practice
Volume 2011, Article ID 856479, 3 pages
Clinical Study

Multiple Coronary Artery Thrombosis in 5,10-Methylenetetrahydrofolate Reductase Gene Mutation

Department of Cardiology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Via F. Sforza, 35 20122 Milano, Italy

Received 19 April 2011; Revised 10 July 2011; Accepted 14 July 2011

Academic Editor: Robin Nijveldt

Copyright © 2011 Alfonso Campanile et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 42-year-old man presented at our attention with chest pain. His cardiac risk factors were smoking habit and family history of coronary artery disease. At the ECG, a mild ST-segment elevation in the inferior leads was shown. A normal left ventricular function was demonstrated at the echocardiography. An emergency coronary angiography was performed, and an extensive thrombosis of the right coronary artery and midleft anterior descending coronary artery was visualized. A primary angioplasty with thrombus aspiration and direct stenting of both sites followed. Biochemical analysis revealed a high plasma homocysteine level with a homozygotic anomaly of the 5,10-methylenetetrahydrofolate reductase. Currently, a nine-month followup negative for cardiac events is recorded.