Research Article

Effect of Preoperative Atrial Fibrillation on Postoperative Outcome following Cardiac Surgery

Table 5

Summary of previously published studies examining the effect of preoperative atrial fibrillation (A Fib) on outcome following cardiac surgery.

First author/yearType of study/numberMain findingslimitations/comment

Ngaage et al. [4], 2006Retrospective
(1) A Fib patients had significantly lower survival at 1, 5, and 7 years than sinus rhythm patients.
(2) A Fib patients had higher incidences of stroke, congestive heart failure and rhythm-related intervention on followup.
(3) A Fib was an independent predictor of late adverse cardiac and cerebrovascular events but not late death.
(4) A trend towards increase in-hospital mortality among A Fib patients.
(1) Patients were matched for age, gender, and ejection fraction.
(2) Only included aortic valve replacements.

Rogers et al. [5], 2006Retrospective (1) A Fib occurred in 3.4% of patients undergoing isolated elective CABG.
(2) No difference in hospital mortality between sinus rhythm and A Fib patients.
(3) A Fib patients had longer hospital stay and higher requirement of intraaortic balloon pump.
(4) A Fib patients had 49% higher risk of death after 5 years of surgery than sinus rhythm patients.
(1) Only elective CABG (on-pump and off-pump).
(2) Limited morbidities were examined.

Ngaage et al. [6], 2007Retrospective

(matched analysis)
(1) A Fib occurred in 8.3% of patients undergoing isolated CABG.
(2) Operative mortality was similar between sinus rhythm and A Fib patients.
(3) A Fib patients had longer hospitalization.
(4) A Fib patients had more late hospital admission (median followup 6.7 years).
(5) A Fib patients had 40% higher late mortality risk from all causes compared to sinus rhythm patients with more MACE in A Fib patients.
(6) A Fib patients had 2.1 relative risk of pacemaker insertion than sinus rhythm patients.
(1) Only on-pump CABG included.
(2) Small sample size overall.
(3) Only examined MACE, stroke, mortality and hospital stay.

Banach et al. [7], 2008Retrospective (1) A Fib patients had lower survival at 6, 12, and 36 months post CABG.
(2) A Fib was an independent risk factor for in-hospital death.
(3) A Fib patients had 20% lower survival difference than sinus rhythm patients.
(4) A Fib was associated with prolonged ventilation, low output state and prolonged hospital stay and ICU stay
Only CABG patients were included.
The risks of other major complications were not evaluated.

Fukahara et al. [8], 2010Retrospective (1) Preoperative A Fib occurred in 5.1% of patients.
(2) No difference in operative mortality between A Fib and sinus rhythm patients.
(3) A Fib patients had significantly lower survival at 5 years than sinus rhythm patients (70% versus 87%).
(4) Freedom from cerebral complications was significantly decreased in A Fib patients.
(5) No difference in cardiac mortality or MACE at 5 years.
(6) A Fib was a significant adverse predictor of survival and independent predictor of late cerebral infarction.
(1) Only off-pump CABG included.
(2) Transient ischemic attacks and cerebral haemorrhages were not counted as cerebrovascular events.
(3) Sample size was small to detect early association between A Fib and postoperative mortality or morbidity.
(4) Postoperative morbidities were not examined.

ICU: intensive care unit.
MACE: major adverse cardiac events.