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Cardiology Research and Practice
Volume 2012, Article ID 319205, 4 pages
Research Article

CRT-D Therapy in Patients with Decompensated NYHA Class-Four CHF

1Hartford Hospital, University of Connecticut, Hartford, CT 06102, USA
2Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA
3Department of Pharmacy, Hartford Hospital, Hartford, CT 06102, USA
4Department of Electrophysiology, Hartford Hospital, Hartford, CT 06102, USA
5CHF Department, Hartford Hospital, Hartford, CT 06102, USA

Received 9 January 2012; Revised 4 June 2012; Accepted 22 June 2012

Academic Editor: John A. Elefteriades

Copyright © 2012 Faisal Zaeem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. ACC-HRS Guidelines for Cardiac Resynchronization Therapy ICD implantation (CRT-D) do not include patients with advanced nonambulatory NYHA class-four CHF due to an expectation of limited survival. There is little data available from these large multicenter randomized studies to support or refute this claim. Purpose. We evaluated the outcomes of patients with advanced nonambulatory NYHA class-four CHF who received CRT-D devices as an attempt to improve the clinical status and promote hospital discharge. Methods. Sixteen (of our six hundred and seventy CRT-D patients) were classified as advanced nonambulatory NYHA Class four inotrope/vasodilator/diuretic-dependent patients. These patients were analyzed retrospectively for weaning success to oral medications, hospital discharge, hemodynamic stability, and survival over eighteen months. Results. Thirteen of sixteen patients were discharged to home within two weeks of implantation. The survival to hospital discharge, as well as at six, twelve, and eighteen months was positive (ninety-four percent, seventy-five percent, sixty-nine percent, sixty-nine percent, resp.). The groups showed significant improvements in systolic blood pressure, renal function, left ventricular ejection fraction, and CHF class. Conclusion. CRT-D in advanced nonambulatory NYHA four patients proved feasible and beneficial. These findings suggest that the strategy merits further study.