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Cardiology Research and Practice
Volume 2012 (2012), Article ID 348054, 8 pages
http://dx.doi.org/10.1155/2012/348054
Research Article

The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure

1Department of Psychology, Kent State University, Kent, OH 44242, USA
2Department of Psychiatry, Summa Health System, Akron City Hospital, Akron, OH 44307, USA
3Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA
4Department of Cardiology, Rhode Island Medical Center, Providence, RI 02903, USA
5Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA
6Department of Kinesiology, University of Wisconsin, Madison, WI 53706, USA
7Department of Medicine, Case Medical Center, University Hospitals, Cleveland, OH 44106, USA
8Harrington Heart & Vascular Institute, Cleveland, OH 44106, USA
9School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA

Received 15 January 2012; Accepted 8 April 2012

Academic Editor: Jill Gelow

Copyright © 2012 Michael L. Alosco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. L. Roger, S. A. Weston, M. M. Redfield et al., “Trends in heart failure incidence and survival in a community-based population,” The Journal of the American Medical Association, vol. 292, no. 3, pp. 344–350, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. W. H. Barker, J. P. Mullooly, and W. Getchell, “Changing incidence and survival for heart failure in a well-defined older population, 1970–1974 and 1990–1994,” Circulation, vol. 113, no. 6, pp. 799–805, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. F. Jencks, M. V. Williams, and E. A. Coleman, “Rehospitalizations among patients in the medicare fee-for-service program,” The New England Journal of Medicine, vol. 360, no. 14, pp. 1418–1428, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. Lloyd-Jones et al., “Heart disease and stroke statistics—2010 update: a report from the American Heart Association,” Circulation, vol. 121, no. 12, Article ID e260, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. S. J. Bennett, N. B. Oldridge, G. J. Eckert et al., “Comparison of quality of life measures in heart failure,” Nursing Research, vol. 52, no. 4, pp. 207–216, 2003. View at Google Scholar · View at Scopus
  6. M. L. Alosco, M. B. Spitznagel, R. Cohen et al., “Cognitive impairment is independently associated with reduced instrumental activities of daily living in persons with heart failure,” The Journal of Cardiovascular Nursing, vol. 27, no. 1, pp. 44–50, 2012. View at Google Scholar · View at Scopus
  7. Y. Seo, B. L. Roberts, I. Piña, and M. Dolansky, “Predictors of motor tasks essential for daily activities among persons with heart failure,” Journal of Cardiac Failure, vol. 14, no. 4, pp. 296–302, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Rengo, D. Acanfora, L. Trojano et al., “Congestive heart failure in the elderly,” Archives of Gerontology and Geriatrics, vol. 23, no. 3, pp. 201–223, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Qiu, W. Xu, B. Winblad, and L. Fratiglioni, “Vascular risk profiles for dementia and Alzheimer's disease in very old people: a population-based longitudinal study,” Journal of Alzheimer's Disease, vol. 20, no. 1, pp. 293–300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. R. L. C. Vogels, P. Scheltens, J. M. Schroeder-Tanka, and H. C. Weinstein, “Cognitive impairment in heart failure: a systematic review of the literature,” European Journal of Heart Failure, vol. 9, no. 5, pp. 440–449, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Zuccalà, G. Onder, C. Pedone et al., “Cognitive dysfunction as a major determinant of disability in patients with heart failure: results from a multicentre survey,” Journal of Neurology Neurosurgery and Psychiatry, vol. 70, no. 1, pp. 109–112, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. J. D. Putzke, M. A. Williams, F. J. Daniel, R. C. Bourge, and T. J. Boll, “Activities of daily living among heart transplant candidates: neuropsychological and cardiac function predictors,” Journal of Heart and Lung Transplantation, vol. 19, no. 10, pp. 995–1006, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Zuccalà, C. Pedone, M. Cesari et al., “The effects of cognitive impairment on mortality among hospitalized patients with heart failure,” American Journal of Medicine, vol. 115, no. 2, pp. 97–103, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Zuccalà, E. Marzetti, M. Cesari et al., “Correlates of cognitive impairment among patients with heart failure: results of a multicenter survey,” American Journal of Medicine, vol. 118, no. 5, pp. 496–502, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. P. M. Pullicino, V. G. Wadley, L. A. McClure et al., “Factors contributing to global cognitive impairment in heart failure: results from a population-based cohort,” Journal of Cardiac Failure, vol. 14, no. 4, pp. 290–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Mauro, G. L. Rosso, M. Peano et al., “Correlation between cognitive impairment and prognostic parameters in patients with congestive heart failure,” Archives of Medical Research, vol. 38, no. 2, pp. 234–239, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J. B. Braunstein, G. F. Anderson, G. Gerstenblith et al., “Noncardiac comorbidity increases preventable hospitalizations and mortality among medicare beneficiaries with chronic heart failure,” Journal of the American College of Cardiology, vol. 42, no. 7, pp. 1226–1233, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Stewart and D. Liolitsa, “Type 2 diabetes mellitus, cognitive impairment and dementia,” Diabetic Medicine, vol. 16, no. 2, pp. 93–112, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Ott, R. P. Stolk, F. van Harskamp, H. A. P. Pols, A. Hofman, and M. M. B. Breteler, “Diabetes mellitus and the risk of dementia: the Rotterdam study,” Neurology, vol. 53, no. 9, pp. 1937–1942, 1999. View at Google Scholar · View at Scopus
  20. D. G. Bruce, G. P. Casey, V. Grange et al., “Cognitive impairment, physical disability and depressive symptoms in older diabetic patients: the Fremantle Cognition in Diabetes Study,” Diabetes Research and Clinical Practice, vol. 61, no. 1, pp. 59–67, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Maggi, F. Limongi, M. Noale et al., “Diabetes as a risk factor for cognitive decline in older patients,” Dementia and Geriatric Cognitive Disorders, vol. 27, no. 1, pp. 24–33, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. A. L. Fischer, C. M. de Frias, S. E. Yeung, and R. A. Dixon, “Short-term longitudinal trends in cognitive performance in older adults with type 2 diabetes,” Journal of Clinical and Experimental Neuropsychology, vol. 31, no. 7, pp. 809–822, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. L. Christman, T. D. Vannorsdall, G. D. Pearlson, F. Hill-Briggs, and D. J. Schretlen, “Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sample,” Archives of Clinical Neuropsychology, vol. 25, no. 1, pp. 49–59, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Fujita, A. Lauten, B. Goebel et al., “Impact of diabetes mellitus on quality of life in patients with congestive heart failure,” Quality of Life Research. In press.
  25. American Heart Association, “Classes of Heart Failure,” 2012, http://www.heart.org/HEARTORG/Conditions/HeartFailure/AboutHeartFailure/Classes-of-Heart-Failure_UCM_306328_Article.jsp#.T2od2pi4JSU.
  26. E. L. Teng and H. C. Chui, “The Modified Mini-Mental State (MMS) examination,” Journal of Clinical Psychiatry, vol. 48, no. 8, pp. 314–318, 1987. View at Google Scholar · View at Scopus
  27. O. Spreen and E. Strauss, A Compendium of Neuropsychological Tests, Oxford University Press, New York, NY, USA, 1991.
  28. A. Smith, “Clinical psychological practice and principals of neuropsychological assessment,” in Handbook of Clinical Psychology: Theory, Research, and Practice, C. Walker, Ed., Dorsey Press, Homewood, Ill, USA, 1983. View at Google Scholar
  29. S. S. Dikmen, R. K. Heaton, I. Grant, and N. R. Temkin, “Test-retest reliability and practice effects of expanded halstead-reitan neuropsychological test battery,” Journal of the International Neuropsychological Society, vol. 5, no. 4, pp. 346–356, 1999. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Wechsler, Manual for the Wechsler Adult Intelligence Scale, The Psychological Corporation, San Antonio, Tex, USA, 3rd edition, 1997.
  31. D. Delis, J. Kramer, E. Kaplan, and B. Ober, California Verbal Learning Test, Psychological Corporation, San Antonio, Tex, USA, 2nd edition, 2000.
  32. K. A. Hawkins, W. H. Sledge, J. F. Orleans, D. M. Quinlan, J. Rakfeldt, and R. E. Hoffman, “Normative implications of the relationship between reading vocabulary and Boston Naming Test performance,” Archives of Clinical Neuropsychology, vol. 8, no. 6, pp. 525–537, 1993. View at Publisher · View at Google Scholar · View at Scopus
  33. J. C. Morris, A. Heyman, R. C. Mohs et al., “The consortium to establish a registry for Alzheimer's disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease,” Neurology, vol. 39, no. 9, pp. 1159–1165, 1989. View at Google Scholar · View at Scopus
  34. H. Klove, “Clinical neuropsychology,” in The Medical Clinics of North America, F. M. Forster, Ed., Saunders, New York, NY, USA, 1963. View at Google Scholar
  35. R. M. Ruff and S. B. Parker, “Gender- and age-specific changes in motor speed and eye-hand coordination in adults: normative values for the finger tapping and grooved pegboard tests,” Perceptual and Motor Skills, vol. 76, no. 3, pp. 1219–1230, 1993. View at Google Scholar · View at Scopus
  36. J. E. Ware, M. Kosinski, and S. D. Keller, “A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity,” Medical Care, vol. 34, no. 3, pp. 220–233, 1996. View at Google Scholar · View at Scopus
  37. M. P. Lawton and E. M. Brody, “Assessment of older people: self-maintaining and instrumental activities of daily living,” Gerontologist, vol. 9, no. 3, pp. 179–186, 1969. View at Google Scholar · View at Scopus
  38. A. T. Beck, R. A. Steer, and G. K. Brown, Beck Depression Inventory, Psychological Corporation, San Antonio, Tex, USA, 2nd edition, 1996.
  39. R. C. Arnau, M. W. Meagher, M. P. Norris, and R. Bramson, “Psychometric evaluation of the beck depression inventory-II with primary care medical patients,” Health Psychology, vol. 20, no. 2, pp. 112–119, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. C. J. Jones and R. E. Rikli, “Measuring functional fitness of older adults,” The Journal on Active Aging, pp. 24–30, 2002. View at Google Scholar
  41. P. A. Nixon, M. L. Joswiak, and F. J. Fricker, “A six-minute walk test for assessing exercise tolerance in severely ill children,” The Journal of Pediatrics, vol. 129, no. 3, pp. 362–366, 1996. View at Publisher · View at Google Scholar · View at Scopus
  42. V. Bittner, D. H. Weiner, S. Yusuf et al., “Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction,” The Journal of the American Medical Association, vol. 270, no. 14, pp. 1702–1707, 1993. View at Publisher · View at Google Scholar · View at Scopus
  43. M. L. Alosco, M. B. Spitznagel, N. Raz et al., “The 2-minute step test is independently associated with cognitive function in older adults with heart failure,” Aging and Clinical Experimental Research. In press.
  44. A. Rózańska-Kirschke, P. Kocur, M. Wilk, and P. Dylewicz, “Fullerton fitness test as fitness index for the elderly,” Rehabilitacja Medyczna, vol. 10, no. 2, pp. 9–16, 2006. View at Google Scholar · View at Scopus
  45. L. Trojano, R. A. Incalzi, D. Acanfora, C. Picone, P. Mecocci, and F. Rengo, “Cognitive impairment: a key feature of congestive heart failure in the elderly,” Journal of Neurology, vol. 250, no. 12, pp. 1456–1463, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. C. L. Dahle, B. S. Jacobs, and N. Raz, “Aging, vascular risk, and cognition: blood glucose, pulse pressure, and cognitive performance in healthy adults,” Psychology and Aging, vol. 24, no. 1, pp. 154–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. P. M. Pullicino and J. Hart, “Cognitive impairment in congestive heart failure? Embolism vs hypoperfusion,” Neurology, vol. 57, no. 11, pp. 1945–1946, 2001. View at Google Scholar · View at Scopus
  48. M. J. Legato, A. Gelzer, R. Goland et al., “Gender-specific care of the patient with diabetes: review and recommendations,” Gender Medicine, vol. 3, no. 2, pp. 131–158, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. A. P. Cannatà, M. Alberoni, M. Franceschi, and C. Mariani, “Frontal impairment in subcortical ischemic vascular dementia in comparison to Alzheimer's disease,” Dementia and Geriatric Cognitive Disorders, vol. 13, no. 2, pp. 101–111, 2002. View at Publisher · View at Google Scholar · View at Scopus
  50. L. C. Perlmuter, M. K. Hakami, and C. Hodgson-Harrington, “Decreased cognitive function in aging non-insulin-dependent diabetic patients,” American Journal of Medicine, vol. 77, no. 6, pp. 1043–1048, 1984. View at Google Scholar · View at Scopus
  51. W. Farris, S. Mansourian, Y. Chang et al., “Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 7, pp. 4162–4167, 2003. View at Publisher · View at Google Scholar · View at Scopus
  52. G. S. Watson, E. R. Peskind, S. Asthana et al., “Insulin increases CSF Aβ42 levels in normal older adults,” Neurology, vol. 60, no. 12, pp. 1899–1903, 2003. View at Google Scholar · View at Scopus
  53. J. Hardy and D. J. Selkoe, “The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics,” Science, vol. 297, no. 5580, pp. 353–356, 2002. View at Publisher · View at Google Scholar · View at Scopus
  54. S. E. Yeung, A. L. Fischer, and R. A. Dixon, “Exploring effects of type 2 diabetes on cognitive functioning in older adults,” Neuropsychology, vol. 23, no. 1, pp. 1–9, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. C. M. Ryan, T. M. Williams, T. J. Orchard, and D. N. Finegold, “Psychomotor slowing is associated with distal symmetrical polyneuropathy in adults with diabetes mellitus,” Diabetes, vol. 41, no. 1, pp. 107–113, 1992. View at Google Scholar · View at Scopus
  56. A. M. A. Brands, G. J. Biessels, E. H. F. de Haan, L. J. Kappelle, and R. P. C. Kessels, “The effects of type 1 diabetes on cognitive performance: a meta-analysis,” Diabetes Care, vol. 28, no. 3, pp. 726–735, 2005. View at Publisher · View at Google Scholar · View at Scopus
  57. R. A. Dixon, D. D. Garrett, T. L. Lentz, S. W. S. MacDonald, E. Strauss, and D. F. Hultsch, “Neurocognitive markers of cognitive impairment: exploring the roles of speed and inconsistency,” Neuropsychology, vol. 21, no. 3, pp. 381–399, 2007. View at Publisher · View at Google Scholar · View at Scopus
  58. J. R. Festa, X. Jia, K. Cheung et al., “Association of low ejection fraction with impaired verbal memory in older patients with heart failure,” Archives of Neurology, vol. 68, no. 8, pp. 1021–1026, 2011. View at Google Scholar
  59. O. I. Okereke, J. H. Kang, N. R. Cook et al., “Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults,” Journal of the American Geriatrics Society, vol. 56, no. 6, pp. 1028–1036, 2008. View at Publisher · View at Google Scholar · View at Scopus
  60. C. Lazzeri, S. Valente, and P. Attanà, “Acute hyperglycemia and insulin resistance in acute heart failure syndromes without previously known diabetes,” Internal and Emergency Medicine. In press. View at Publisher · View at Google Scholar
  61. W. Doehner, D. Gathercole, M. Cicoira et al., “Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition,” International Journal of Cardiology, vol. 138, no. 1, pp. 19–24, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. Z. S. Tan, A. S. Beiser, C. S. Fox et al., “Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the framingham offspring study,” Diabetes Care, vol. 34, no. 8, pp. 1766–1770, 2011. View at Google Scholar
  63. D. G. Feil, A. Pearman, T. Victor et al., “The role of cognitive impairment and caregiver support in diabetes management of older outpatients,” International Journal of Psychiatry in Medicine, vol. 39, no. 2, pp. 199–214, 2009. View at Publisher · View at Google Scholar · View at Scopus
  64. E. Cipolletta, A. Campanile, G. Santulli et al., “The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance,” Cardiovascular Research, vol. 84, no. 3, pp. 407–415, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. G. Rengo, D. Leosco, C. Zincarelli et al., “Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure,” American Journal of Physiology, vol. 298, no. 6, pp. H2032–H2038, 2010. View at Publisher · View at Google Scholar · View at Scopus
  66. S. Craft and G. S. Watson, “Insulin and neurodegenerative disease: shared and specific mechanisms,” The Lancet Neurology, vol. 3, no. 3, pp. 169–178, 2004. View at Publisher · View at Google Scholar · View at Scopus
  67. K. van den Hurk, Y. D. Reijmer, E. van den Berg et al., “Heart failure and cognitive function in the general population: the Hoorn study,” European Journal of Heart Failure, vol. 13, no. 12, pp. 1362–1369, 2011. View at Google Scholar