Cardiology Research and Practice / 2012 / Article / Fig 5

Research Article

Protective Function of STAT3 in CVB3-Induced Myocarditis

Figure 5

Collagen expression and expression of the ECM degrading system in cardiac tissue of CVB3-infected mice. The area fractions of collagen I and collagen III are shown 10 and 28 days after CVB3 infection of WT and STAT3 KO mice as x-fold compared to the corresponding untreated controls. The mRNA expression data of MMP13 and TIMP1 are normalized to the house-keeping gene 18S and to the expression levels of the corresponding untreated mice and expressed as x-fold over basal expression using the formula 2 Δ Δ C t . The ratios were calculated without previous normalization to the untreated controls. * Data were compared to the expression of the corresponding untreated controls. * 𝑃 < 0 . 0 5 ; ** 𝑃 < 0 . 0 1 ; *** 𝑃 < 0 . 0 0 1 . §Data between WT and STAT3 KO mice were compared. § 𝑃 < 0 . 0 5 ; §§ 𝑃 < 0 . 0 1 . #Data between 10 or 28 days were compared. # 𝑃 < 0 . 0 5 .
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