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Cardiology Research and Practice
Volume 2012, Article ID 587194, 7 pages
http://dx.doi.org/10.1155/2012/587194
Review Article

Baroreflex Activation Therapy for the Treatment of Drug-Resistant Hypertension: New Developments

Department of Internal Medicine, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands

Received 13 February 2012; Accepted 23 April 2012

Academic Editor: Andrejs Erglis

Copyright © 2012 Teba Alnima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. J. M. Scheffers, A. A. Kroon, J. Schmidli et al., “Novel baroreflex activation therapy in resistant hypertension: results of a European multi-center feasibility study,” Journal of the American College of Cardiology, vol. 56, no. 15, pp. 1254–1258, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. D. Bisognano, G. Bakris, M. K. Nadim et al., “Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal trial,” Journal of the American College of Cardiology, vol. 58, no. 7, pp. 765–773, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. A. J. Dunning, The Carotid Sinus Reflex. Electrostimulation of the Carotid Sinus in Angina Pectoris, Royal VanGorcum, Amsterdam, The Netherlands, 1971.
  4. H. R. Kirchheim, “Systemic arterial baroreceptor reflexes,” Physiological Reviews, vol. 56, no. 1, pp. 100–177, 1976. View at Google Scholar · View at Scopus
  5. E. E. Benarroch, “The arterial baroreflex: functional organization and involvement in neurologic disease,” Neurology, vol. 71, no. 21, pp. 1733–1738, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Papademetriou, M. Doumas, C. Faselis et al., “Carotid baroreceptor stimulation for the treatment of resistant hypertension,” International Journal of Hypertension, vol. 2011, Article ID 964394, 5 pages, 2011. View at Publisher · View at Google Scholar
  7. M. Doumas, D. Guo, and V. Papademetriou, “Carotid baroreceptor stimulation as a therapeutic target in hypertension and other cardiovascular conditions,” Expert Opinion on Therapeutic Targets, vol. 13, no. 4, pp. 413–425, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Katz, “Depolarization of sensory terminals and the initiation of impulses in the muscle spindle,” The Journal of Physiology, vol. 111, no. 3-4, pp. 261–282, 1950. View at Google Scholar
  9. M. W. Chapleau, Z. Li, S. S. Meyrelles, X. Ma, and F. M. Abboud, “Mechanisms determining sensitivity of baroreceptor afferents in health and disease,” Annals of the New York Academy of Sciences, vol. 940, pp. 1–19, 2001. View at Google Scholar · View at Scopus
  10. Y. Lu, X. Ma, R. Sabharwal et al., “The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation,” Neuron, vol. 64, no. 6, pp. 885–897, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. Brown, “Receptors under pressure. An update on baroreceptors,” Circulation Research, vol. 46, no. 1, pp. 1–10, 1980. View at Google Scholar · View at Scopus
  12. J. W. McCubbin, J. H. Green, and I. H. Page, “Baroceptor function in chronic renal hypertension,” Circulation Research, vol. 4, no. 2, pp. 205–210, 1956. View at Google Scholar
  13. M. W. Chapleau, G. Hajduczok, and F. M. Abboud, “Mechanisms of resetting of arterial baroreceptors: an overview,” American Journal of the Medical Sciences, vol. 295, no. 4, pp. 327–334, 1988. View at Google Scholar · View at Scopus
  14. E. M. Krieger, “Arterial baroreceptor resetting in hypertension,” Clinical and Experimental Pharmacology and Physiology, vol. 16, no. 15, pp. 3–17, 1989. View at Google Scholar · View at Scopus
  15. T. N. Thrasher, “Baroreceptors, baroreceptor unloading, and the long-term control of blood pressure,” American Journal of Physiology, vol. 288, no. 4, pp. R819–R827, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. P. G. Guyenet, “The sympathetic control of blood pressure,” Nature Reviews Neuroscience, vol. 7, no. 5, pp. 335–346, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. A. A. Kroon, J. Schmidli, I. Scheffers et al., “Sustained blood pressure reduction by baroreflex activation therapy with a chronically implanted system: 4-year data of Rheos Debut-Ht study in patients with resistant hypertension: 9D.01,” Journal of Hypertension, vol. 28, article e441, 2010. View at Publisher · View at Google Scholar
  18. T. E. Lohmeier, E. D. Irwin, M. A. Rossing, D. J. Serdar, and R. S. Kieval, “Prolonged activation of the baroreflex produces sustained hypotension,” Hypertension, vol. 43, no. 2, pp. 306–311, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Heusser, J. Tank, S. Engeli et al., “Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients,” Hypertension, vol. 55, no. 3, pp. 619–626, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Wustmann, J. P. Kucera, I. Scheffers et al., “Effects of chronic baroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension,” Hypertension, vol. 54, no. 3, pp. 530–536, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. A. W. Cowley Jr., J. F. Liard, and A. C. Guyton, “Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs,” Circulation Research, vol. 32, no. 5, pp. 564–576, 1973. View at Google Scholar · View at Scopus
  22. P. I. Korner, “Baroreceptor resetting and other determinants of baroreflex properties in hypertension,” Clinical and Experimental Pharmacology and Physiology, vol. 16, no. 15, pp. 45–64, 1989. View at Google Scholar · View at Scopus
  23. A. C. Guyton, “Blood pressure control—special role of the kidneys and body fluids,” Science, vol. 252, no. 5014, pp. 1813–1816, 1991. View at Google Scholar · View at Scopus
  24. P. Sleight, “The importance of the autonomic nervous system in health and disease,” Australian and New Zealand Journal of Medicine, vol. 27, no. 4, pp. 467–473, 1997. View at Google Scholar · View at Scopus
  25. T. N. Thrasher, “Baroreceptors and the long-term control of blood pressure,” Experimental Physiology, vol. 89, no. 4, pp. 331–335, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. G. L. Bakris, M. K. Nadim, H. Haller, E. G. Lovett, J. E. Schafer, and J. D. Bisognano, “Baroreflex activation therapy provides durable benefit in patients with resistant hypertension: results of long-term follow-up in the Rheos Pivotal Trial,” Journal of the American Society of Hypertension, vol. 6, no. 2, pp. 152–158, 2012. View at Publisher · View at Google Scholar
  27. I. J. M. Scheffers, A. A. Kroon, and P. W. de Leeuw, “Carotid baroreflex activation: past, present, and future,” Current Hypertension Reports, vol. 12, no. 2, pp. 61–66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. W. Grossman, “Complications of carotid-sinus stimulation,” The New England Journal of Medicine, vol. 281, no. 2, article 103, 1969. View at Google Scholar · View at Scopus
  29. I. J. M. Scheffers, A. A. Kroon, J. H. M. Tordoir, and P. W. de Leeuw, “Rheos baroreflex hypertension therapy system to treat resistant hypertension,” Expert Review of Medical Devices, vol. 5, no. 1, pp. 33–39, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. J. H. M. Tordoir, I. Scheffers, J. Schmidli et al., “An implantable carotid sinus baroreflex activating system: surgical technique and short-term outcome from a multi-center feasibility trial for the treatment of resistant hypertension,” European Journal of Vascular and Endovascular Surgery, vol. 33, no. 4, pp. 414–421, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Schmidli, H. Savolainen, F. Eckstein et al., “Acute device-based blood pressure reduction: electrical activation of the carotid baroreflex in patients undergoing elective carotid surgery,” Vascular, vol. 15, no. 2, pp. 63–69, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. D. A. Sica, J. D. Bisognano, M. K. Nadim, L. Sanchez, and G. Bakris, “Individualized programming demonstrates feasibility of unilateral approach to delivery of baroreflex activation therapy,” The Journal of Clinical Hypertension, vol. 13, supplement 1, article A10, 2011. View at Google Scholar
  33. M. Tafil-Klawe, F. Raschke, and G. Hildebrandt, “Functional asymmetry in carotid sinus cardiac reflexes in humans,” European Journal of Applied Physiology and Occupational Physiology, vol. 60, no. 5, pp. 402–405, 1990. View at Publisher · View at Google Scholar · View at Scopus
  34. J. W. Williamson, M. Muzi, and T. J. Ebert, “Unilateral carotid sinus stimulation and muscle sympathetic nerve activity in man,” Medicine and Science in Sports and Exercise, vol. 28, no. 7, pp. 815–821, 1996. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Furlan, A. Diedrich, A. Rimoldi et al., “Effects of unilateral and bilateral carotid baroreflex stimulation on cardiac and neural sympathetic discharge oscillatory patterns,” Circulation, vol. 108, no. 6, pp. 717–723, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. J. W. Williamson and P. B. Raven, “Unilateral carotid-cardiac baroreflex responses in humans,” American Journal of Physiology, vol. 265, part 2, no. 4, pp. H1033–H1037, 1993. View at Google Scholar · View at Scopus
  37. K. Sagawa and K. Watanabe, “Summation of bilateral carotid sinus signals in the barostatic reflex,” The American Journal of Physiology, vol. 209, no. 6, pp. 1278–1286, 1965. View at Google Scholar · View at Scopus
  38. G. Hasenfuss, “New generation barostim neo system: preliminary results and discussion,” in ESC 2011 Barostim Symposium, Paris, France, 2011.
  39. M. Brandt, R. Wachter, J. Beige et al., “Minimally-invasive system for baroreflex activation therapy chronically reduces blood pressure: initial results from the Barostim neo trial,” Journal of the American College of Cardiology, vol. 59, no. 13, Article ID E1784, 2012. View at Publisher · View at Google Scholar
  40. A. A. Kroon, J. D. Bisognano, D. S. Bach, C. L. Kaufman, and P. W. de Leeuw, “Baroreflex activation therapy improves functional capacity and reduces left ventricular mass index. Results from European and United States trials of the Rheos system,” Journal of Hypertension, vol. 28, article e278, 2010. View at Google Scholar
  41. P. W. de Leeuw, D. Gangahar, D. Bach, and E. G. Lovett, “Investigators D-HaRFS. Left ventricular reverse remodeling with chronic treatment of resistant hypertension using an implantable device: results from European and United States trials of the Rheos Baroreflex hypertension therapy system,” Journal of Hypertension, vol. 26, supplement 1, article S471, 2008. View at Google Scholar
  42. J. D. Bisognano, C. L. Kaufman, D. S. Bach, E. G. Lovett, and P. de Leeuw, “Improved cardiac structure and function with chronic treatment using an implantable device in resistant hypertension: results from European and United States trials of the Rheos system,” Journal of the American College of Cardiology, vol. 57, no. 17, pp. 1787–1788, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. J. D. Bisognano, G. Bakris, M. K. Nadim, L. Sanchez, and D. A. Sica, “Baroreflex hypertension therapy improves cardiac structure and function in resistant hypertension: results from the Pivotal trial of the Rheos system,” Journal of the American College of Cardiology, vol. 57, article E491, 2011. View at Google Scholar
  44. D. Georgakopoulos, W. C. Little, W. T. Abraham, F. A. Weaver, and M. R. Zile, “Chronic baroreflex activation: a potential therapeutic approach to heart failure with preserved ejection fraction,” Journal of Cardiac Failure, vol. 17, no. 2, pp. 167–178, 2011. View at Publisher · View at Google Scholar · View at Scopus