The Association of Chronic Kidney Disease and Metabolic Syndrome with Incident Cardiovascular Events: Multiethnic Study of Atherosclerosis

Table 3

Estimates of multiplicative and additive interaction (95% confidence interval, CI) controlling for covariates.

	CKD × MetS
Parameters	Estimate	95% CI	P-value
𝛽3	0.48	−0.23, 1.28	0.2
RERI	2.73	0.57, 4.85	0.02
AP	0.49	0.24, 0.74
SI	2.49	1.24, 4.98

CKD: chronic kidney disease; MetS: metabolic syndrome; 𝛽₃: parameter estimate of CKD × MetS testing for multiplicative interaction; RERI: relative excess risk due to additive interaction; AP: attributable portion; SI: synergy index are measures testing for additive interaction.