High-Sensitivity Troponin T: A Biomarker for Diuretic Response in Decompensated Heart Failure Patients

Table 4

Associations with at day 1, day 3 and changes between day 1 and day 3 (Δ).

	Nonadjusted coefficient for	95%CI	value	Adjusted coefficient for	95%CI	Value
Age	0,119	−0,001 to 0,005	0,240
Male sex	−0,066	−0,086 to 0,043	0,515
DM	0,095	−0,033 to 0,093	0,349
HgBA1c	0,058	−0,046 to 0,067	0,707
LVEF	0,089	−0,001 to 0,004	0,376
Ischemic HF	−0,078	−0,087 to 0,038	0,442
Beta-blocker	−0,004	−0,065 to 0,062	0,969
ACEi	0,023	−0,057 to 0,072	0,820
Spironolactone	−0,116	−0,099 to 0,026	0,251
BMI
Day 1	−0,205	−0,025 to 0,000	0,042
Day 3	−0,087	−0,016 to 0,006	0,391
ΔBMI	−0,008	−0,019 to 0,018	0,937
HR
Day 1	0,063	−0,002 to 0,004	0,533
Day 3	−0,078	−0,008 to 0,004	0,438
ΔHR	0,013	−0,001 to 0,001	0,899
SBP
Day 1	0,102	−0,001 to 0,004	0,314
Day 3	0,098	−0,002 to 0,006	0,333
ΔSBP	0,207	0,000 to 0,003	0,039
Day 1	0,481	0,267 to 0,574	<0,001	0,400	0,185 to 0,513	<0,001
Day 3	0,486	0,218 to 0,464	<0,001	0,381	0,146 to 0,389	<0,001
Δ	0,267	0,044 to 0,276	0,007	—	—	—
Day 1	0,131	−0,035 to 0,172	0,193
Day 3	0,220	0,012 to 0,203	0,028	0,088	−0,041 to 0,128	0,311
Δ	0,099	−0,038 to 0,113	0,325
Day 1	−0,275	−1,231 to −0,216	0,006	0,165	−0,503 to 1,372	0,360
Day 3	−0,399	−1,232 to −0,455	<0,001	0,034	−0,812 to 0,957	0,870
Δ	0,068	0,203 to 0,413	0,502
Day 1	0,345	0,500 to 1,704	<0,001	0,270	−0,224 to 1,951	0,118
Day 3	0,439	0,630 to 1,503	<0,001	0,256	−0,393 to 1,641	0,226
Δ	−0,040	−0,443 to 0,297	0,696
pUrea
Day 1	0,309	0,002 to 0,009	0,002	0,116	−0,002 to 0,007	0,342
Day 3	0,382	0,003 to 0,008	<0,001	0,121	−0,002 to 0,005	0,335
ΔpUrea	−0,172	−0,003 to 0,000	0,087
Albumin at day 1	−0,049	−0,099 to 0,060	0,626
Hemoglobin at day 1	0,076	−0,009 to 0,021	0,451

Day 1 values are compared with day 1 hsTnT; day 3 values are compared with day 3 hsTnT; Δ, age, sex, DM, HgBA1c, LVEF, ischemic HF, and medications are compared with changes (Δ) in hsTnT between day 1 and day 3 (day 3–day 1).
DM: diabetes mellitus; HgBA1c: glycated hemoglobin; LVEF: left ventricular ejection fraction; HF: heart failure; ACEi: angiotensin converting enzyme inhibitors; BMI: body mass index; HR: heart rate; SBP: systolic blood pressure; NTproBNP: N-terminal probrain natriuretic peptide; hsTnT: high sensitivity troponin T; eGFR: estimated glomerular filtration rate; pCr: plasma creatinine; pUrea: plasma urea; Δ: changes between day 3 and day 1 (day 3–day 1).