Cardiology Research and Practice / 2014 / Article / Tab 5

Clinical Study

High-Sensitivity Troponin T: A Biomarker for Diuretic Response in Decompensated Heart Failure Patients

Table 5

Determinants of hsTnT dichotomic changes.

hsTnT value
Decrease Increase

Age (years)75,94 ± 11,9276,11 ± 8,970,940
Male sex—no. (%)22 (34,9)17 (45,9)0,275**
DM—no. (%)24 (38,1)21 (56,8)0,070**
HGA1c (%)6,93 ± 0,947,13 ± 1,000,475
Sleep apnea—no. (%)7 (36,8)11 (44)0,632**
NIV—no. (%)10 (15,9)7 (18,9)0,695**
IHD—no. (%)32 (50,8)18 (48,6)0,836**
AF—no. (%)31 (49,2)28 (75,7)0,009 **
LVEF (%)43,37 ± 12,6843,62 ± 10,080,917
LVEF ≥40%—no. (%)41 (65,1)26 (70,3)0,594**
HgB (g/dL)12,32 ± 1,9512,62 ± 2,280,478
Albumin (mg/dL)3,68 ± 0,413,67 ± 0,390,924
ΔBMI (Kg/m2)−1,08 ± 1,70−1,10 ± 1,760,964
ΔHR (bpm)−17,05 ± 20,71−17,57 ± 29,150,917
ΔSBP (mmHg)−18,56 ± 23,32−16,57 ± 27,630,702
ΔpCr (mg/dL)0,03 [−0,1 to 0,18]0,02 [−0,06 to 0,11]0,803*
ΔeGFR (mL/min/1,73 m2)−2,0 [−9,0 to 7,0]−1,0 [−11,0 to 6,0]0,937*
ΔpUrea (mg/dL)7,40 ± 20,596,59 ± 20,650,851
ΔNTproBNP (pg/mL)−1167 [−2337 to −367]−379 [−1273 to 319,5]0,003 *
ΔhsTnT (ng/mL)−0,004 [−0,014 to −0,001]0,004 [0,002 to 0,009]<0,001 *
ΔAlbuminuria (mg/g)−6,10 [−38,50 to 2,40]−23,70 [−90,75 to 11,05]0,337*
IV furosemide at day 1 (mg)78,83 ± 21,6174,05 ± 21,530,537
IV furosemide dose
Maintenance or increase at day 3—no. (%)9 (14,3)7 (18,9)0,542**
ACEi—no. (%)30 (47,6)14 (37,8)0,341**
Beta-blocker—no (%)22 (34,9)15 (40,5)0,574**
Spironolactone—no. (%)30 (47,6)20 (54,1)0,534**
Length of stay (days)8,0 [6,0 to 11,0]9,0 [7,0 to 12,0]0,033 *

Continuous variables are presented as mean value ± standard deviation SD, value or median [interquartile range (IQR)], value. Categorical variables are presented as absolute number (%), value.
*Nonparametric paired sample test; **chi-square test.
DM: diabetes mellitus; HgBA1c: glycated hemoglobin; NIV: noninvasive ventilation; IHD: ischemic heart disease; AF: atrial fibrillation; HgB: hemoglobin; BMI: body mass index; HR: heart rate; SBP: systolic blood pressure; eGFR: estimated glomerular filtration rate; pCr: plasma creatinine; pUrea: plasma urea; NTproBNP: N-terminal probrain natriuretic peptide; hsTnT: high sensitivity troponin T; IV: intravenous; ACEi: angiotensin converting enzyme inhibitors; Δ: changes between day 3 and day 1 (day 3–day 1).