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Cardiology Research and Practice
Volume 2014, Article ID 281483, 7 pages
http://dx.doi.org/10.1155/2014/281483
Review Article

Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis

1Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India
2Department of Cardiology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India
3ICMR Advanced Centre for Evidence-Based Child Health, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India
4Dr. Tulsidas Library, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India

Received 10 September 2013; Accepted 7 November 2013; Published 30 January 2014

Academic Editor: Frans Leenen

Copyright © 2014 Navjot Kaur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Terminalia arjuna is a popular Indian medicinal plant with its bark been used for over centuries as cardiotonic. The bark has been found to contain several bioactive compounds including saponins and flavonoids. A number of experimental and clinical studies have been conducted to explore therapeutic potential of Terminalia arjuna in cardiovascular ailments specially in patients of coronary heart disease. A number of narrative reviews have been done but no systematic review has been conducted to date. Objective. To systematically review and conduct a meta-analysis on the available literature evaluating the efficacy of Terminalia arjuna in patients of chronic stable angina. Study selection. We included randomised, pseudo-randomized and before-after comparative studies which compared Terminalia arjuna/commercial preparation of Terminalia arjuna with current standard/ conventional treatment regimens in patients with chronic stable angina. Findings. Studies were found to be of poor methodological design. We found no significant difference in the Terminalia arjuna group as compared to control arm in the outcomes for which we were able to pool data and undertake meta-analysis. Conclusions. Currently, the evidence is insufficient to draw any definite conclusions in favour of or against Terminalia arjuna in patients of chronic stable angina. Further, well-controlled multicentric clinical trials need to be conducted in large number of patients to explore the therapeutic potential of Terminalia arjuna if any.