Neutralization by Insulin of the Hypertensive Effect of Dermcidin Isoform 2: An Environmentally Induced Diabetogenic and Hypertensive Protein
Figure 1
The effect of different stress factors on the systemic increase of dermcidin level. Three groups of mice ( in each group) were exposed to pure nicotine, tobacco leaves free aqueous extract, and hypoxia. The dermcidin level was measured in the blood of these animals as described in Section 2 by ELISA using anti-dermcidin antibody at different times as shown. Solid squares (■) represent the plasma level of dermcidin in mice injected with 50 pmol of nicotine/25 g body weight. Solid triangles (▲) represent the dermcidin level in mice administered with 0.1 mL of the tobacco leaves free aqueous extract. Solid circles (●) indicate the dermcidin level in mice exposed to hypoxia. Hollow squares (□) indicate the dermcidin level in mice not subjected to any stress factors. The results shown are mean ± SD of 10 different experiments using different animals, each in triplicate.
