Neutralization by Insulin of the Hypertensive Effect of Dermcidin Isoform 2: An Environmentally Induced Diabetogenic and Hypertensive Protein
Figure 3
The effect of the ingestion of aspirin on the dermcidin level and systolic and diastolic blood pressure levels in humans. Aspirin at a bolus dose of 150 mg/70 kg body weight was ingested orally by hypertensive subjects as described above. The plasma dermcidin level and blood pressure level (both systolic and diastolic) were determined in these patients before and after the ingestion of the compound. Panel (a) represents the dermcidin level in the hypertensive subjects. Solid squares (■) represent the dermcidin levels before the ingestion of aspirin. Hollow squares (□) indicate the dermcidin levels after the ingestion of aspirin by the hypertensive subjects. Panel (b) represents the systolic blood pressure in the hypertensive subjects. Solid circles (●) demonstrate the systolic blood pressure level before the ingestion of aspirin. Hollow circles (○) show the systolic blood pressure after the ingestion of the compound. Panel (c) demonstrates the diastolic blood pressure in the subjects suffering from hypertension. Solid triangles (▲) represent the level of diastolic blood pressure before the oral ingestion of aspirin. Hollow triangles (∆) indicate the diastolic blood pressure levels after the ingestion of aspirin. The figure is a typical representative of 10 different experiments using the blood samples of 40 hypertensive volunteers (, ), 35–45 years, each experiment in triplicate.
