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Cardiology Research and Practice
Volume 2014, Article ID 454701, 7 pages
Research Article

Mean Platelet Volume in Patients with Obstructive Sleep Apnea and Its Relationship with Simpler Heart Rate Derivatives

1Department of Cardiology, Faculty of Medicine, Namık Kemal University, 59100 Tekirdağ, Turkey
2Department of Internal Medicine, Faculty of Medicine, Namık Kemal University, 59100 Tekirdağ, Turkey
3Department of Neurology, Faculty of Medicine, Namık Kemal University, 59100 Tekirdağ, Turkey

Received 28 July 2014; Revised 26 August 2014; Accepted 29 August 2014; Published 10 September 2014

Academic Editor: Frans Leenen

Copyright © 2014 Aydın Akyüz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some studies show increased mean platelet volume (MPV) in obstructive sleep apnea (OSA). The aim of this study was to evaluate MPV in OSA patients without cardiovascular risk factors and the possible association of heart rate derivatives with MPV. A total of 82 patients (aged 30–70 years) were divided into 2 groups according to the presence of either OSA or non-OSA as the control group. The OSA group consisted of 52 patients and the control group consisted of 30 subjects. Neither group was significantly different in terms of MPV values as well as heart rate (HR) derivatives such as minimum HR, maximum HR, the difference between maximum HR and minimum HR, mean HR, and heart rate performance index (HRPI) [(HR max. − HR min.)/HR mean] (P > 0.05 for all variables). In multivariate analysis, platelet count and percentages of recording time spent at arterial oxygen saturation < 90% significant variables are associated with MPV (: −0.004 ± 0.002, 95% CI, −0.008 to −0.001; P = 0.034) and (: 2.93 ± 1.93, 95% CI, 0.167 to 5.69; P = 0.038). Consequently, our findings predominantly suggest that there is a casual and reciprocal interaction between MPV and autonomic activation.