Serum CRP levels in patients with MI predict mortality up to 6 months after the event. Highest levels were found between the 2nd and 4th days after infarction, the highest mean concentration being 65 mg/L; IC: 58–71 in patients who survived 24 months.
245 patients (80 deceased due to CVD after 5-year follow-up)
CRP is a powerful yet unspecific risk factor for CVD in the elderly. Serum CRP levels of those who died due to CVD were twice as high than those of control subjects (5.7 mg/L versus 2.7 mg/L; ).
CRP is an independent predictor of mortality short- and long-term in ACS patients without ST segment elevation who received early invasive treatment. In-hospital mortality was 1.2% in patients with (<3 mg/L), 0.8% (1–3 mg/L), and 3.7% (>10 mg/L), with RR = 4.2 for mortality.
After multiple adjustments, patients with serum CRP levels 1–3 mg/L had a greater mortality risk (HR: 2.3; IC: 1.2–4.6) in comparison with those with levels <1 mg/L. The mortality risk for patients >3 mg/L was even higher (HR: 3.7; IC: 1.9–7.2).
CRP is modest yet independent predictor of mortality within the first month after ACS. Subjects with levels >22 mg/L (4th quartile) had 4 times greater mortality risk within 30 days.
Patients with the highest serum CRP levels (4th quartile) presented a greater mortality risk within 30 days in comparison to the 1st quartile (2.3 versus 1.3%; ), as well as within a year after the event (5.5 versus 2.8%; ).
