Table 5: Goals for lowering LDL-C [173].

Risk categoryLDL-C goalsRecommendations

Lower risk
 0-1 major risk factor
 10-yr risk <10%
<160 mg/dLLifestyle modifications
Consider pharmacotherapy if LDL-C ≥190 mg/dL after lifestyle modifications

Moderate risk
 ≥2 major risk factors
 10-yr risk <10%
<130 mg/dLLifestyle modifications
Consider pharmacotherapy if LDL-C ≥160 mg/dL after lifestyle modifications

Moderately high risk
 ≥2 major risk factors
 10-yr risk 10–20%
<130 mg/dL
Optional <100 mg/dL
Lifestyle modifications
Consider pharmacotherapy if LDL-C ≥130 mg/dL or optionally ≥100 mg/dL after lifestyle modifications

High risk
 CHD or CHD risk equivalents
<100 mg/dL
Optional <70 mg/dL
Lifestyle modifications
Consider pharmacotherapy if LDL-C ≥100 mg/dL or optionally ≥70 mg/dL after lifestyle modifications