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Cardiology Research and Practice
Volume 2015, Article ID 380729, 8 pages
Research Article

Determinants and Regression Equations for the Calculation of Scores of Left Ventricular Tissue Doppler Longitudinal Indexes in a Healthy Italian Pediatric Population

1Cardiology Unit, S. Maria Annunziata Hospital, Florence 50012, Italy
2Department of Pediatric Cardiology, Meyer Hospital, Florence 50139, Italy
3Regional Health Agency of Tuscany, Florence 50141, Italy

Received 29 July 2015; Accepted 1 November 2015

Academic Editor: Vicky A. Cameron

Copyright © 2015 Veronica Fibbi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. We investigated the predictors of tissue Doppler left ventricular (LV) longitudinal indexes in a healthy Italian pediatric population and established normative data and regression equations for the calculation of scores. Methods and Results. A total of 369 healthy subjects aged 1–17 years (age of 6.4 ± 1.1 years, 49.1% female) underwent echocardiography. LV peak longitudinal velocity at systole (), early diastole (), and late diastole () was determined by tissue Doppler. The ratio of peak early diastolic LV filling velocity to was calculated. Age was the only independent determinant of (, ) and the strongest determinant of (, ) and (, ). Heart rate was the main determinant of (, ). Male gender showed no effects except for a weak association with lateral , suggesting no need of gender-specific reference ranges. Age-specific reference ranges, regression equations, and scatterplots for the calculation of scores were determined for each index. Conclusion. In a pediatric Italian population, age was the strongest determinant of LV longitudinal dynamics. The availability of age-specific normality data for the calculation of scores may allow for correctly detecting LV dysfunction in pediatric pathological populations.