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Cardiology Research and Practice
Volume 2015, Article ID 802840, 8 pages
Research Article

Calcification Characteristics of Low-Flow Low-Gradient Severe Aortic Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement

1University Heart Center, Department of Cardiology, University Hospital Zürich, 8091 Zürich, Switzerland
2Institute of Diagnostic and Interventional Radiology, University Hospital Zürich, 8091 Zürich, Switzerland
3University Heart Center, Department of Cardiovascular Surgery, University Hospital Zürich, 8091 Zürich, Switzerland

Received 24 June 2015; Accepted 20 August 2015

Academic Editor: G. Thiene

Copyright © 2015 Barbara E. Stähli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Low-flow low-gradient severe aortic stenosis (LFLGAS) is associated with worse outcomes. Aortic valve calcification patterns of LFLGAS as compared to non-LFLGAS have not yet been thoroughly assessed. 137 patients undergoing transcatheter aortic valve replacement (TAVR) with preprocedural multidetector computed tomography (MDCT) and postprocedural transthoracic echocardiography were enrolled. Calcification characteristics were assessed by MDCT both for the total aortic valve and separately for each leaflet. 34 patients had LFLGAS and 103 non-LFLGAS. Total aortic valve calcification volume (), mass (), and density () were lower in LFLGAS as compared to non-LFLGAS patients. At 30-day follow-up, mean transaortic pressure gradients and more than mild paravalvular regurgitation did not differ between groups. In conclusion, LFLGAS and non-LFLGAS express different calcification patterns which, however, did not impact on device success after TAVR.