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Cardiology Research and Practice
Volume 2016 (2016), Article ID 2579832, 12 pages
http://dx.doi.org/10.1155/2016/2579832
Review Article

Postinfarct Left Ventricular Remodelling: A Prevailing Cause of Heart Failure

Alessio Galli and Federico Lombardi

Cardiovascular Diseases Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Clinical and Community Sciences, University of Milan, Via F. Sforza 35, 20122 Milan, Italy

Received 31 October 2015; Revised 13 January 2016; Accepted 17 January 2016

Academic Editor: Stephan von Haehling

Copyright © 2016 Alessio Galli and Federico Lombardi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. S. Go, D. Mozaffarian, V. L. Roger et al., “Heart disease and stroke statistics—2014 update: a report from the American heart association,” Circulation, vol. 129, no. 3, pp. e28–e292, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. P. T. O'Gara, F. G. Kushner, D. D. Ascheim et al., “2013 ACCF/AHA Guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines,” Journal of the American College of Cardiology, vol. 61, no. 4, pp. e78–e140, 2013. View at Publisher · View at Google Scholar
  3. E. C. Keeley and L. D. Hillis, “Primary PCI for myocardial infarction with ST-segment elevation,” The New England Journal of Medicine, vol. 356, no. 1, pp. 47–54, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. D. S. Menees, E. D. Peterson, Y. Wang et al., “Door-to-balloon time and mortality among patients undergoing primary PCI,” The New England Journal of Medicine, vol. 369, no. 10, pp. 901–909, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Windecker, J. J. Bax, A. Myat, G. W. Stone, and M. S. Marber, “Future treatment strategies in ST-segment elevation myocardial infarction,” The Lancet, vol. 382, no. 9892, pp. 644–657, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. J. J. V. McMurray, S. Adamopoulos, S. D. Anker et al., “ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC,” European Heart Journal, vol. 33, no. 14, pp. 1787–1847, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Dhingra, A. Garg, S. Kaur et al., “Epidemiology of heart failure with preserved ejection fraction,” Current Heart Failure Reports, vol. 11, no. 4, pp. 354–365, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. S. A. Hunt, D. W. Baker, M. H. Chin et al., “ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee to revise the 1995 guidelines for the evaluation and management of heart failure) developed in collaboration with the International Society for Heart and Lung Transplantation Endorsed by the Heart Failure Society of America,” Journal of the American College of Cardiology, vol. 38, no. 7, pp. 2101–2113, 2001. View at Publisher · View at Google Scholar
  9. G. M. Fröhlich, P. Meier, S. K. White, D. M. Yellon, and D. J. Hausenloy, “Myocardial reperfusion injury: looking beyond primary PCI,” European Heart Journal, vol. 34, no. 23, pp. 1714–1724, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. M. A. Konstam, D. G. Kramer, A. R. Patel, M. S. Maron, and J. E. Udelson, “Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment,” JACC: Cardiovascular Imaging, vol. 4, no. 1, pp. 98–108, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Verma, A. Meris, H. Skali et al., “Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (Valsartan in Acute Myocardial Infarction) Echocardiographic Study,” JACC: Cardiovascular Imaging, vol. 1, no. 5, pp. 582–591, 2008. View at Publisher · View at Google Scholar
  12. J. Ganame, G. Messalli, P. G. Masci et al., “Time course of infarct healing and left ventricular remodelling in patients with reperfused ST segment elevation myocardial infarction using comprehensive magnetic resonance imaging,” European Radiology, vol. 21, no. 4, pp. 693–701, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. J. J. Gomez-Doblas, J. Schor, P. Vignola et al., “Left ventricular geometry and operative mortality in patients undergoing mitral valve replacement,” Clinical Cardiology, vol. 24, no. 11, pp. 717–722, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. F. A. Flachskampf, M. Schmid, C. Rost, S. Achenbach, A. N. Demaria, and W. G. Daniel, “Cardiac imaging after myocardial infarction,” European Heart Journal, vol. 32, no. 3, pp. 272–283, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. G. Masci, J. Ganame, M. Francone et al., “Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodelling,” European Heart Journal, vol. 32, no. 13, pp. 1640–1648, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Springeling, S. W. Kirschbaum, A. Rossi et al., “Late cardiac remodeling after primary percutaneous coronary intervention—five-year cardiac magnetic resonance imaging follow-up,” Circulation Journal, vol. 77, no. 1, pp. 81–88, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Casella, M. Cassin, F. Chiarella et al., “Epidemiology and patterns of care of patients admitted to Italian Intensive Cardiac Care units: the BLITZ-3 registry,” Journal of Cardiovascular Medicine, vol. 11, no. 6, pp. 450–461, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Bolognese, A. N. Neskovic, G. Parodi et al., “Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications,” Circulation, vol. 106, no. 18, pp. 2351–2357, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Savoye, O. Equine, O. Tricot et al., “Left ventricular remodeling after anterior wall acute myocardial infarction in modern clinical practice (from the REmodelage VEntriculaire [REVE] Study Group),” The American Journal of Cardiology, vol. 98, no. 9, pp. 1144–1149, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. G. K. Lund, A. Stork, K. Muellerleile et al., “Prediction of left ventricular remodeling and analysis of infarct resorption in patients with reperfused myocardial infarcts by using contrast-enhanced MR imaging,” Radiology, vol. 245, no. 1, pp. 95–102, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. C. M. Kramer, A. J. Sinusas, D. E. Sosnovik, B. A. French, and F. M. Bengel, “Multimodality imaging of myocardial injury and remodeling,” Journal of Nuclear Medicine, vol. 51, no. 1, pp. 107S–121S, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. K. H. Darasz, S. R. Underwood, J. Bayliss et al., “Measurement of left ventricular volume after anterior myocardial infarction: comparison of magnetic resonance imaging, echocardiography, and radionuclide ventriculography,” International Journal of Cardiovascular Imaging, vol. 18, no. 2, pp. 135–142, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Prasad and D. Pennell, “Measurement of left ventricular volume after anterior myocardial infarction: comparison of magnetic resonance imaging, echo and radionuclide ventriculography,” The International Journal of Cardiovascular Imaging, vol. 18, no. 5, pp. 387–390, 2002. View at Publisher · View at Google Scholar
  24. A. S. Fauci, E. Braunwald, D. L. Kasper et al., Harrison's Principles of Internal Medicine, McGraw-Hill, 17th edition, 2008.
  25. S.-A. Chang, Y. H. Choe, S. Y. Jang, S. M. Kim, S.-C. Lee, and J. K. Oh, “Assessment of left and right ventricular parameters in healthy Korean volunteers using cardiac magnetic resonance imaging: change in ventricular volume and function based on age, gender and body surface area,” International Journal of Cardiovascular Imaging, vol. 28, no. 2, pp. 141–147, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. J. P. Curtis, S. I. Sokol, Y. Wang et al., “The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure,” Journal of the American College of Cardiology, vol. 42, no. 4, pp. 736–742, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. C. M. Kramer, W. J. Rogers, T. M. Theobald, T. P. Power, G. Geskin, and N. Reichek, “Dissociation between changes in intramyocardial function and left ventricular volumes in the eight weeks after first anterior myocardial infarction,” Journal of the American College of Cardiology, vol. 30, no. 7, pp. 1625–1632, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. L. H. Opie, P. J. Commerford, B. J. Gersh, and M. A. Pfeffer, “Controversies in ventricular remodelling,” The Lancet, vol. 367, no. 9507, pp. 356–367, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. H. B. Hillenbrand, J. Sandstede, S. Störk et al., “Remodeling of the infarct territory in the time course of infarct healing in humans,” Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 24, no. 5, pp. 277–284, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. J. J. W. Sandstede, C. Lipke, W. Kenn, M. Beer, T. Pabst, and D. Hahn, “Cine MR imaging after myocardial infarction—assessment and follow-up of regional and global left ventricular function,” International Journal of Cardiac Imaging, vol. 15, no. 6, pp. 435–440, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Zhong, Y. Su, S.-Y. Yeo, R.-S. Tan, D. N. Ghista, and G. Kassab, “Left ventricular regional wall curvedness and wall stress in patients with ischemic dilated cardiomyopathy,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 296, no. 3, pp. H573–H584, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Zhang, A. K. Y. Chan, C.-M. Yu et al., “Left ventricular systolic asynchrony after acute myocardial infarction in patients with narrow QRS complexes,” American Heart Journal, vol. 149, no. 3, pp. 497–503, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. S.-A. Chang, H.-J. Chang, S. I. Choi et al., “Usefulness of left ventricular dyssynchrony after acute myocardial infarction, assessed by a tagging magnetic resonance image derived metric, as a determinant of ventricular remodeling,” The American Journal of Cardiology, vol. 104, no. 1, pp. 19–23, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. Zhang, G. W. Yip, A. K. Y. Chan et al., “Left ventricular systolic dyssynchrony is a predictor of cardiac remodeling after myocardial infarction,” American Heart Journal, vol. 156, no. 6, pp. 1124–1132, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. D. M. Yellon and D. J. Hausenloy, “Myocardial reperfusion injury,” The New England Journal of Medicine, vol. 357, no. 11, pp. 1074–1135, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. C. M. Kramer, W. J. Rogers, C. S. Park et al., “Regional myocyte hypertrophy parallels regional myocardial dysfunction during post-infarct remodeling,” Journal of Molecular and Cellular Cardiology, vol. 30, no. 9, pp. 1773–1778, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. M.-T. Wu, W.-Y. I. Tseng, M.-Y. M. Su et al., “Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction: correlation with viability and wall motion,” Circulation, vol. 114, no. 10, pp. 1036–1045, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. M.-T. Wu, M.-Y. Su, Y.-L. Huang et al., “Sequential changes of myocardial microstructure in patients postmyocardial infarction by diffusion-tensor cardiac MR: correlation with left ventricular structure and function,” Circulation: Cardiovascular Imaging, vol. 2, no. 1, pp. 32–40, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Mekkaoui, S. Huang, H. H. Chen et al., “Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation,” Journal of Cardiovascular Magnetic Resonance, vol. 14, no. 1, article 70, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Machackova, J. Barta, and N. S. Dhalla, “Myofibrillar remodelling in cardiac hypertrophy, heart failure and cardiomyopathies,” Canadian Journal of Cardiology, vol. 22, no. 11, pp. 953–968, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. W. Grossman and W. J. Paulus, “Myocardial stress and hypertrophy: a complex interface between biophysics and cardiac remodeling,” Journal of Clinical Investigation, vol. 123, no. 9, pp. 3701–3703, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Miyata, W. Minobe, M. R. Bristow, and L. A. Leinwand, “Myosin heavy chain isoform expression in the failing and nonfailing human heart,” Circulation Research, vol. 86, no. 4, pp. 386–390, 2000. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Krenz and J. Robbins, “Impact of beta-myosin heavy chain expression on cardiac function during stress,” Journal of the American College of Cardiology, vol. 44, no. 12, pp. 2390–2397, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. N. Koitabashi and D. A. Kass, “Reverse remodeling in heart failure-mechanisms and therapeutic opportunities,” Nature Reviews Cardiology, vol. 9, no. 3, pp. 147–157, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. L. H. Lehmann, B. C. Worst, D. A. Stanmore, and J. Backs, “Histone deacetylase signaling in cardioprotection,” Cellular and Molecular Life Sciences, vol. 71, no. 9, pp. 1673–1690, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. C. L. Antos, T. A. McKinsey, M. Dreitz et al., “Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors,” The Journal of Biological Chemistry, vol. 278, no. 31, pp. 28930–28937, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. W. Chan, S. J. Duffy, D. A. White et al., “Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion,” JACC: Cardiovascular Imaging, vol. 5, no. 9, pp. 884–893, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Ugander, A. J. Oki, L.-Y. Hsu et al., “Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology,” European Heart Journal, vol. 33, no. 10, pp. 1268–1278, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. T. C. Wong, K. Piehler, C. G. Meier et al., “Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality,” Circulation, vol. 126, no. 10, pp. 1206–1216, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. W. Xin, X. Li, X. Lu, K. Niu, and J. Cai, “Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia,” International Journal of Molecular Medicine, vol. 27, no. 4, pp. 503–509, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. J. J. Gajarsa and R. A. Kloner, “Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities,” Heart Failure Reviews, vol. 16, no. 1, pp. 13–21, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. D. J. Hausenloy and D. M. Yellon, “Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection,” Heart Failure Reviews, vol. 12, no. 3-4, pp. 217–234, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. T. Kempf, M. Eden, J. Strelau et al., “The transforming growth factor-β superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury,” Circulation Research, vol. 98, no. 3, pp. 351–360, 2006. View at Publisher · View at Google Scholar · View at Scopus
  54. R. K. Harston and D. Kuppuswamy, “Integrins are the necessary links to hypertrophic growth in cardiomyocytes,” Journal of Signal Transduction, vol. 2011, Article ID 521742, 8 pages, 2011. View at Publisher · View at Google Scholar
  55. C. Banfi, V. Cavalca, F. Veglia et al., “Neurohormonal activation is associated with increased levels of plasma matrix metalloproteinase-2 in human heart failure,” European Heart Journal, vol. 26, no. 5, pp. 481–488, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. J. Sundström, J. C. Evans, E. J. Benjamin et al., “Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk factors and echocardiographic left ventricular measures: the Framingham heart study,” Circulation, vol. 109, no. 23, pp. 2850–2856, 2004. View at Publisher · View at Google Scholar · View at Scopus
  57. S. Heymans, B. Schroen, P. Vermeersch et al., “Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart,” Circulation, vol. 112, no. 8, pp. 1136–1144, 2005. View at Publisher · View at Google Scholar · View at Scopus
  58. M. Fertin, E. Dubois, A. Belliard, P. Amouyel, F. Pinet, and C. Bauters, “Usefulness of circulating biomarkers for the prediction of left ventricular remodeling after myocardial infarction,” American Journal of Cardiology, vol. 110, no. 2, pp. 277–283, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Force and K. L. Kolaja, “Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes,” Nature Reviews Drug Discovery, vol. 10, no. 2, pp. 111–126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  60. N. R. Madamanchi, S. Li, C. Patterson, and M. S. Runge, “Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, no. 3, pp. 321–326, 2001. View at Publisher · View at Google Scholar · View at Scopus
  61. M. Hori and O. Yamaguchi, “Is tumor necrosis factor-α friend or foe for chronic heart failure?” Circulation Research, vol. 113, no. 5, pp. 492–494, 2013. View at Publisher · View at Google Scholar · View at Scopus
  62. J. W. Gordon, J. A. Shaw, and L. A. Kirshenbaum, “Multiple facets of NF-κB in the heart: to be or not to NF-κB,” Circulation Research, vol. 108, no. 9, pp. 1122–1132, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. G. M. Ellison, D. Torella, S. Dellegrottaglie et al., “Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart,” Journal of the American College of Cardiology, vol. 58, no. 9, pp. 977–986, 2011. View at Publisher · View at Google Scholar · View at Scopus
  64. G. M. Cote, D. B. Sawyer, and B. A. Chabner, “ERBB2 inhibition and heart failure,” The New England Journal of Medicine, vol. 367, no. 22, pp. 2150–2153, 2012. View at Publisher · View at Google Scholar · View at Scopus
  65. M. Jougasaki, “Cardiotrophin-1 in cardiovascular regulation,” Advances in Clinical Chemistry, vol. 52, pp. 41–76, 2010. View at Publisher · View at Google Scholar
  66. E. Letavernier, L. Zafrani, J. Perez, B. Letavernier, J.-P. Haymann, and L. Baud, “The role of calpains in myocardial remodelling and heart failure,” Cardiovascular Research, vol. 96, no. 1, pp. 38–45, 2012. View at Publisher · View at Google Scholar · View at Scopus
  67. W. T. Pu, Q. Ma, and S. Izumo, “NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro,” Circulation Research, vol. 92, no. 7, pp. 725–731, 2003. View at Publisher · View at Google Scholar · View at Scopus
  68. X. Zhang, C. Szeto, E. Gao et al., “Cardiotoxic and cardioprotective features of chronic β-Adrenergic signaling,” Circulation Research, vol. 112, no. 3, pp. 498–509, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. R. S. Whelan, K. Konstantinidis, R.-P. Xiao, and R. N. Kitsis, “Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling,” Circulation Research, vol. 112, no. 3, pp. 408–410, 2013. View at Publisher · View at Google Scholar · View at Scopus
  70. S. D. Solomon, H. Skali, N. S. Anavekar et al., “Changes in ventricular size and function in patients treated with valsartan, captopril, or both after myocardial infarction,” Circulation, vol. 111, no. 25, pp. 3411–3419, 2005. View at Publisher · View at Google Scholar · View at Scopus
  71. R. E. Foster, D. B. Johnson, F. Barilla et al., “Changes in left ventricular mass and volumes in patients receiving angiotensin-converting enzyme inhibitor therapy for left ventricular dysfunction after Q-wave myocardial infarction,” American Heart Journal, vol. 136, no. 2, pp. 269–275, 1998. View at Publisher · View at Google Scholar · View at Scopus
  72. M. Hayashi, T. Tsutamoto, A. Wada et al., “Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction,” Circulation, vol. 107, no. 20, pp. 2559–2565, 2003. View at Publisher · View at Google Scholar · View at Scopus
  73. J. N. Cohn, R. Ferrari, and N. Sharpe, “Cardiac remodelling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling,” Journal of the American College of Cardiology, vol. 35, pp. 569–582, 2000. View at Google Scholar
  74. A. L. Taylor, S. Ziesche, C. Yancy et al., “Combination of isosorbide dinitrate and hydralazine in blacks with heart failure,” The New England Journal of Medicine, vol. 351, no. 20, pp. 2049–2057, 2004. View at Publisher · View at Google Scholar · View at Scopus
  75. F. G. Spinale and F. Villarreal, “Targeting matrix metalloproteinases in heart disease: lessons from endogenous inhibitors,” Biochemical Pharmacology, vol. 90, no. 1, pp. 7–15, 2014. View at Publisher · View at Google Scholar · View at Scopus
  76. A. Jabbour, C. S. Hayward, A. M. Keogh et al., “Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses,” European Journal of Heart Failure, vol. 13, no. 1, pp. 83–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  77. R. Gao, J. Zhang, L. Cheng et al., “A phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure,” Journal of the American College of Cardiology, vol. 55, no. 18, pp. 1907–1914, 2010. View at Publisher · View at Google Scholar · View at Scopus
  78. S. Neubauer and C. Redwood, “New mechanisms and concepts for cardiac-resynchronization therapy,” The New England Journal of Medicine, vol. 370, no. 12, pp. 1164–1166, 2014. View at Publisher · View at Google Scholar · View at Scopus
  79. S. Klotz, A. H. Jan Danser, and D. Burkhoff, “Impact of left ventricular assist device (LVAD) support on the cardiac reverse remodeling process,” Progress in Biophysics and Molecular Biology, vol. 97, no. 2-3, pp. 479–496, 2008. View at Publisher · View at Google Scholar · View at Scopus
  80. K. Takeda, T. Sakaguchi, S. Miyagawa et al., “The extent of early left ventricular reverse remodelling is related to midterm outcomes after restrictive mitral annuloplasty in patients with non-ischaemic dilated cardiomyopathy and functional mitral regurgitation,” European Journal of Cardiothoracic Surgery, vol. 41, no. 3, pp. 506–511, 2012. View at Publisher · View at Google Scholar · View at Scopus
  81. M. R. Costanzo, R. J. Ivanhoe, A. Kao et al., “Prospective evaluation of elastic restraint to lessen the effects of heart failure (PEERLESS-HF) trial,” Journal of Cardiac Failure, vol. 18, no. 6, pp. 446–458, 2012. View at Publisher · View at Google Scholar · View at Scopus
  82. C. T. Klodell Jr., J. M. Aranda Jr., D. C. McGiffin et al., “Worldwide surgical experience with the Paracor HeartNet cardiac restraint device,” Journal of Thoracic and Cardiovascular Surgery, vol. 135, no. 1, pp. 188–195, 2008. View at Publisher · View at Google Scholar · View at Scopus
  83. S. Ørn, C. Manhenke, I. S. Anand et al., “Effect of left ventricular scar size, location, and transmurality on left ventricular remodeling with healed myocardial infarction,” American Journal of Cardiology, vol. 99, no. 8, pp. 1109–1114, 2007. View at Publisher · View at Google Scholar · View at Scopus
  84. J. Hallén, J. K. Jensen, M. W. Fagerland, A. S. Jaffe, and D. Atar, “Cardiac troponin I for the prediction of functional recovery and left ventricular remodelling following primary percutaneous coronary intervention for ST-elevation myocardial infarction,” Heart, vol. 96, no. 23, pp. 1892–1897, 2010. View at Publisher · View at Google Scholar · View at Scopus
  85. R. Y. Kwong, A. K. Chan, K. A. Brown et al., “Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease,” Circulation, vol. 113, no. 23, pp. 2733–2743, 2006. View at Publisher · View at Google Scholar · View at Scopus
  86. E. Braunwald, “Heart failure,” JACC: Heart Failure, vol. 1, no. 1, pp. 1–20, 2013. View at Publisher · View at Google Scholar · View at Scopus
  87. K. C. Wu, “CMR of microvascular obstruction and hemorrhage in myocardial infarction,” Journal of Cardiovascular Magnetic Resonance, vol. 14, article 68, 2012. View at Publisher · View at Google Scholar · View at Scopus
  88. R. A. P. Weir, C. A. Murphy, C. J. Petrie et al., “Microvascular obstruction remains a portent of adverse remodeling in optimally treated patients with left ventricular systolic dysfunction after acute myocardial infarction,” Circulation: Cardiovascular Imaging, vol. 3, no. 4, pp. 360–367, 2010. View at Publisher · View at Google Scholar · View at Scopus
  89. O. Husser, J. V. Monmeneu, J. Sanchis et al., “Cardiovascular magnetic resonance-derived intramyocardial hemorrhage after STEMI: influence on long-term prognosis, adverse left ventricular remodeling and relationship with microvascular obstruction,” International Journal of Cardiology, vol. 167, no. 5, pp. 2047–2054, 2013. View at Publisher · View at Google Scholar · View at Scopus
  90. A. N. Mather, T. A. Fairbairn, S. G. Ball, J. P. Greenwood, and S. Plein, “Reperfusion haemorrhage as determined by cardiovascular MRI is a predictor of adverse left ventricular remodelling and markers of late arrhythmic risk,” Heart, vol. 97, no. 6, pp. 453–459, 2011. View at Publisher · View at Google Scholar · View at Scopus
  91. J. C. Weaver and J. A. McCrohon, “Contrast-enhanced cardiac MRI in myocardial infarction,” Heart Lung and Circulation, vol. 17, no. 4, pp. 290–298, 2008. View at Publisher · View at Google Scholar · View at Scopus
  92. B. G. Schwartz and R. A. Kloner, “Coronary no reflow,” Journal of Molecular and Cellular Cardiology, vol. 52, no. 4, pp. 873–882, 2012. View at Publisher · View at Google Scholar · View at Scopus
  93. S. C. A. M. Bekkers, S. K. Yazdani, R. Virmani, and J. Waltenberger, “Microvascular obstruction: underlying pathophysiology and clinical diagnosis,” Journal of the American College of Cardiology, vol. 55, no. 16, pp. 1649–1660, 2010. View at Publisher · View at Google Scholar · View at Scopus
  94. D. T. L. Wong, R. Puri, J. D. Richardson, M. I. Worthley, and S. G. Worthley, “Myocardial ‘no-reflow’—diagnosis, pathophysiology and treatment,” International Journal of Cardiology, vol. 167, no. 5, pp. 1798–1806, 2013. View at Publisher · View at Google Scholar · View at Scopus
  95. D. P. O'Regan, R. Ahmed, N. Karunanithy et al., “Reperfusion hemorrhage following acute myocardial infarction: assessment with T2* mapping and effect on measuring the area at risk,” Radiology, vol. 250, no. 3, pp. 916–922, 2009. View at Publisher · View at Google Scholar · View at Scopus
  96. M. I. Zia, N. R. Ghugre, K. A. Connelly et al., “Characterizing myocardial edema and hemorrhage using quantitative T2 and T2∗ mapping at multiple time intervals post ST-segment elevation myocardial infarction,” Circulation: Cardiovascular Imaging, vol. 5, no. 5, pp. 566–572, 2012. View at Publisher · View at Google Scholar
  97. S. Frantz, J. Bauersachs, and G. Ertl, “Post-infarct remodelling: contribution of wound healing and inflammation,” Cardiovascular Research, vol. 81, no. 3, pp. 474–481, 2009. View at Publisher · View at Google Scholar · View at Scopus
  98. A. Kali, A. Kumar, I. Cokic et al., “Chronic manifestation of postreperfusion intramyocardial hemorrhage as regional iron deposition: a cardiovascular magnetic resonance study with ex vivo validation,” Circulation: Cardiovascular Imaging, vol. 6, no. 2, pp. 218–228, 2013. View at Publisher · View at Google Scholar · View at Scopus
  99. R. S. Britton, K. L. Leicester, and B. R. Bacon, “Iron toxicity and chelation therapy,” International Journal of Hematology, vol. 76, no. 3, pp. 219–228, 2002. View at Publisher · View at Google Scholar · View at Scopus
  100. A. Kidambi, A. N. Mather, M. Motwani et al., “The effect of microvascular obstruction and intramyocardial hemorrhage on contractile recovery in reperfused myocardial infarction: insights from cardiovascular magnetic resonance,” Journal of Cardiovascular Magnetic Resonance, vol. 15, article 58, 2013. View at Publisher · View at Google Scholar · View at Scopus
  101. G. Klug, A. Mayr, S. Schenk et al., “Prognostic value at 5 years of microvascular obstruction after acute myocardial infarction assessed by cardiovascular magnetic resonance,” Journal of Cardiovascular Magnetic Resonance, vol. 14, no. 1, article 46, 2012. View at Publisher · View at Google Scholar · View at Scopus
  102. M. Soleimani, M. Khazalpour, G. Cheng et al., “Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction,” Annals of Thoracic Surgery, vol. 92, no. 5, pp. 1614–1620, 2011. View at Publisher · View at Google Scholar · View at Scopus
  103. A. N. Rassi, P. Pibarot, and S. Elmariah, “Left ventricular remodelling in aortic stenosis,” Canadian Journal of Cardiology, vol. 30, no. 9, pp. 1004–1011, 2014. View at Publisher · View at Google Scholar · View at Scopus
  104. A. Ganau, R. B. Devereux, M. J. Roman et al., “Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension,” Journal of the American College of Cardiology, vol. 19, no. 7, pp. 1550–1558, 1992. View at Publisher · View at Google Scholar · View at Scopus
  105. H. P. Krayenbuehl, O. M. Hess, E. S. Monrad, J. Schneider, G. Mall, and M. Turina, “Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement,” Circulation, vol. 79, no. 4, pp. 744–755, 1989. View at Publisher · View at Google Scholar · View at Scopus
  106. A. J. McLellan, M. P. Schlaich, A. J. Taylor et al., “Reverse cardiac remodeling after renal denervation: atrial electrophysiologic and structural changes associated with blood pressure lowering,” Heart Rhythm, vol. 12, no. 5, pp. 982–990, 2015. View at Publisher · View at Google Scholar
  107. L. Nilsson, J. Hallén, D. Atar, L. Jonasson, and E. Swahn, “Early measurements of plasma matrix metalloproteinase-2 predict infarct size and ventricular dysfunction in ST-elevation myocardial infarction,” Heart, vol. 98, no. 1, pp. 31–36, 2012. View at Publisher · View at Google Scholar · View at Scopus
  108. C. J. French, A. K. M. T. Zaman, R. J. Kelm Jr., J. L. Spees, and B. E. Sobel, “Vascular rhexis: loss of integrity of coronary vasculature in mice subjected to myocardial infarction,” Experimental Biology and Medicine, vol. 235, no. 8, pp. 966–973, 2010. View at Publisher · View at Google Scholar · View at Scopus
  109. P. Carmeliet, L. Moons, R. Lijnen et al., “Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation,” Nature Genetics, vol. 17, no. 4, pp. 439–444, 1997. View at Publisher · View at Google Scholar · View at Scopus
  110. S. Ørn, T. Ueland, C. Manhenke et al., “Increased interleukin-1β levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention,” Journal of Internal Medicine, vol. 272, no. 3, pp. 267–276, 2012. View at Publisher · View at Google Scholar · View at Scopus
  111. J. G. Akar and F. G. Akar, “Mapping arrhythmias in the failing heart: from Langendorff to patient,” Journal of Electrocardiology, vol. 39, no. 4, pp. S19–S23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  112. M. Fernández-Velasco, N. Goren, G. Benito, J. Blanco-Rivero, L. Boscá, and C. Delgado, “Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts,” Journal of Physiology, vol. 553, no. 2, pp. 395–405, 2003. View at Publisher · View at Google Scholar · View at Scopus
  113. H. A. Fozzard, “Afterdepolarizations and triggered activity,” Basic Research in Cardiology, vol. 87, no. 2, pp. 105–113, 1992. View at Google Scholar · View at Scopus
  114. U. O. Egolum, D. G. Stover, R. Anthony, A. M. Wasserman, D. Lenihan, and J. B. Damp, “Intracardiac thrombus: diagnosis, complications and management,” The American Journal of the Medical Sciences, vol. 345, no. 5, pp. 391–395, 2013. View at Publisher · View at Google Scholar · View at Scopus
  115. R. A. P. Weir, T. N. Martin, C. J. Petrie et al., “Cardiac and extracardiac abnormalities detected by cardiac magnetic resonance in a post-myocardial infarction cohort,” Cardiology, vol. 113, no. 1, pp. 1–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  116. J. J. V. McMurray, M. Packer, A. S. Desai et al., “Angiotensin-neprilysin inhibition versus enalapril in heart failure,” The New England Journal of Medicine, vol. 371, no. 11, pp. 993–1004, 2014. View at Publisher · View at Google Scholar · View at Scopus
  117. K. Leineweber, P. Rohe, A. Beilfuß et al., “G-protein-coupled receptor kinase activity in human heart failure: effects of β-adrenoceptor blockade,” Cardiovascular Research, vol. 66, no. 3, pp. 512–519, 2005. View at Publisher · View at Google Scholar · View at Scopus
  118. Å. Hjalmarson, “Effects of beta blockade on sudden cardiac death during acute myocardial infarction and the postinfarction period,” The American Journal of Cardiology, vol. 80, no. 9, pp. 35J–39J, 1997. View at Google Scholar · View at Scopus
  119. S. P. Jones and R. Bolli, “The ubiquitous role of nitric oxide in cardioprotection,” Journal of Molecular and Cellular Cardiology, vol. 40, no. 1, pp. 16–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  120. J. Inserte and D. Garcia-Dorado, “The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism,” British Journal of Pharmacology, vol. 172, no. 8, pp. 1996–2009, 2015. View at Publisher · View at Google Scholar
  121. R. A. Kloner, “Current state of clinical translation of cardioprotective agents for acute myocardial infarction,” Circulation Research, vol. 113, no. 4, pp. 451–463, 2013. View at Publisher · View at Google Scholar · View at Scopus
  122. M. Jessup, B. Greenberg, D. Mancini et al., “Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure,” Circulation, vol. 124, no. 3, pp. 304–313, 2011. View at Publisher · View at Google Scholar · View at Scopus