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Cardiology Research and Practice
Volume 2016 (2016), Article ID 3582380, 17 pages
http://dx.doi.org/10.1155/2016/3582380
Review Article

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling

1Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 10, Novosibirsk 630090, Russia
2Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Academy Lavrentyev Avenue 8, Novosibirsk 630090, Russia
3State Research Institute of Circulation Pathology, Rechkunovskaya Street 15, Novosibirsk 630055, Russia
4Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia

Received 26 November 2015; Accepted 3 March 2016

Academic Editor: Vicky A. Cameron

Copyright © 2016 Daniel R. Bayzigitov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes.