Review Article
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling
Table 1
Electrophysiological characteristics of heart that differ in humans and laboratory animals (modified from [
91]).
| | | Mouse | Rat | Guinea pig | Rabbit | Dog | Human |
| | Heart rate (bpm) | 500 | 300 | 230 | 200 | 70 | 75 | | Coronary collaterals | Variable | Low | High | None | Middle | Low | | Ventricular AP duration (ms) | 25–40 | 50 | 140 | 120–140 | 250 | 250 | | Primary repolarizing current | | | | | | | | Q wave in ECG | No | No | Yes | Yes | Yes | Yes | | ST segment in ECG | No | No | Yes | Yes | Yes | Yes |
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