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Cardiology Research and Practice
Volume 2016, Article ID 3708210, 9 pages
Research Article

Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series

1Clinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, Italy
2Centro Integrato di Ricerche (CIR), Laboratory of Clinical Pathology and Microbiology, University “Campus Bio-Medico”, Via Alvaro del Portillo 200, 00128 Rome, Italy
3Internal Medicine Department, University Hospital Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Rome, Italy
4Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Received 1 December 2015; Accepted 1 February 2016

Academic Editor: Stephan von Haehling

Copyright © 2016 Silvia Angeletti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Patients with acute decompensated heart failure (ADHF) frequently develop worsening in renal function until Acute Kidney Injury (AKI). The use of kidney injury biomarkers could be useful in the early diagnosis of AKI. In the present study, the role of the neutrophil gelatinase-associated lipocalin (NGAL), compared to the standard creatinine, in ADHF patients, was analyzed to evaluate if an early treatment could affect the outcome. A case series of 24 ADHF patients was enrolled and patients randomly divided in two groups (Group A and Group B). In Group A, NGAL, creatinine, and eGFR were measured, while in Group B, creatinine and eGFR alone were measured. NGAL was measured by turbidimetric immunoassay and creatinine using an enzymatic spectrophotometric method. In presence of AKI, creatinine increase and eGFR decrease were significantly lower in Group A than in Group B, whereas in absence of AKI the difference between the two groups was not significant. Hospitalization stay was significantly lower in Group A (receiving early treatment based on NGAL) than in Group B. In ADHF patients, plasma NGAL in combination with creatinine was superior to the standard creatinine in the diagnosis and early treatment of AKI with a better outcome and a decreased hospital stay.