Table of Contents Author Guidelines Submit a Manuscript
Cardiology Research and Practice
Volume 2016 (2016), Article ID 5106127, 5 pages
Research Article

Comparison between First- and Second-Generation Cryoballoon for Paroxysmal Atrial Fibrillation Ablation

1Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, Italy
2St. Jude Medical, Agrate Brianza, Italy

Received 12 November 2015; Accepted 8 February 2016

Academic Editor: Kai Hu

Copyright © 2016 Sergio Conti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Cryoballoon (CB) ablation has emerged as a novel treatment for pulmonary vein isolation (PVI) for patients with paroxysmal atrial fibrillation (PAF). The second-generation Arctic Front Advance (ADV) was redesigned with technical modifications aiming at procedural and outcome improvements. We aimed to compare the efficacy of the two different technologies over a long-term follow-up. Methods. A total of 120 patients with PAF were enrolled. Sixty patients underwent PVI using the first-generation CB and 60 patients with the ADV catheter. All patients were evaluated over a follow-up period of 2 years. Results. There were no significant differences between the two groups of patients. Procedures performed with the first-generation CB showed longer fluoroscopy time ( versus  min, resp.; ) and longer procedure times as well ( versus  min, resp.; ). The overall long-term success was significantly different between the two groups (68.3 versus 86.7%, resp.; ). No differences were found in the lesion areas of left and right PV between the two groups (resp., and ). There were no significant differences in procedural-related complications. Conclusion. The ADV catheter compared to the first-generation balloon allows obtaining a significantly higher success rate after a single PVI procedure during the long-term follow-up. Fluoroscopy and procedural times were significantly shortened using the ADV catheter.