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Cardiology Research and Practice
Volume 2016 (2016), Article ID 5172308, 7 pages
Review Article

The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature

1Mayo Clinic, 200 First Street SW, Rochester, MN 55902, USA
2Lehigh Valley Health Network, 1250 S Cedar Crest Boulevard, Allentown, PA 18103, USA

Received 5 June 2015; Revised 7 October 2015; Accepted 13 October 2015

Academic Editor: Hugo A. Katus

Copyright © 2016 Courtney E. Bennett and Ronald Freudenberger. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Isolated left ventricular noncompaction (LVNC) is a genetic cardiomyopathy characterized by prominent ventricular trabeculations and deep intertrabecular recesses, or sinusoids, in communication with the left ventricular cavity. The low prevalence of patients with this cardiomyopathy presents a unique challenge for large, prospective trials to assess its pathogenesis, management, and outcomes. In this paper we review the embryology and genetics of LVNC, the diagnostic approach, and propose a management approach based on the current literature available.