Thymoquinone Ameliorates Doxorubicin-Induced Cardiotoxicity in Swiss Albino Mice by Modulating Oxidative Damage and Cellular Inflammation
Table 2
The effect of thymoquinone on antioxidant enzymes in doxorubicin-mediated cardiotoxicity in the mice.
Groups and treatments
CAT (nmole of H2O2 consumed/min/mg/protein)
SOD (nmol epinephrine protected from oxidation/min/mg protein)
GPx (nmol NADPH oxidized/min/mg/protein)
GR (nmol NADPH oxidized/min/mg protein)
GST (nmol CDNB conjugate/min/mg protein)
Group A (control)
35.93 ± 2.4
12.51 ± 1.56
160.05 ± 3.10
415.89 ± 1.34
159.79 ± 4.56
Group B (DOX)
15.34 ± 2.60
5.29 ± 1.78
83.94 ± 3.72
217.38 ± 2.34
80.26 ± 4.21
Group C (DOX + Q10)
38.23 ± 2.30
8.45 ± 1.58
115.34 ± 2.14
384.13 ± 2.13
120.46 ± 3.54
Group D (DOX + TQ-20)
34.45 ± 2.11
10.34 ± 1.36
143.67 ± 2.13
420.22 ± 1.65
159.87 ± 2.45
Group E TQ-20
30.23 ± 1.23
13.56 ± 2.10
167.45 ± 1.46
428.00 ± 1.34
156.08 ± 2.33
Each value is the mean of six replicates with standard deviation; ,, and were significant when compared to normal control (Group A) and toxic control (Group-B) by performing Tukey–Kramer test.
