Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis
Table 4
Echocardiographic characteristics between baseline and follow-up.
Total cohort
Slow progression (Pmean < 5 mmHg/year)
Fast Progression (Pmean ≥ 5 mmHg/year)
value
LVEDD (mm)
Baseline
47.9 ± 8.6
48.4 ± 8.9
47.0 ± 7.9
0.11
Follow-up
47.86 ± 8.5
48.2 ± 8.9
47.2 ± 7.7
0.23
IVSd (mm)
Baseline
11.5 ± 2.2
11.5 ± 2.2
11.6 ± 2.2
0.58
Follow-up
11.4 ± 2.3
11.2 ± 2.5
11.9 ± 1.9
0.001
LVPWd (mm)
Baseline
11.2 ± 2.0
11.2 ± 2.0
11.3 ± 2.0
0.43
Follow-up
11.1 ± 2.0
10.9 ± 2.0
11.7 ± 1.8
<0.001
LVEF (%)
Baseline
53.8 ± 11.5
52.8 ± 11.5
55.7 ± 11.2
0.020
Follow-up
51.4 ± 12.4
50.1 ± 13.0
53.9 ± 10.7
0.002
LAD (mm)
Baseline
41.5 ± 6.6
41.4 ± 6.9
41.8 ± 6.0
0.62
Follow-up
42.7 ± 6.6
42.7 ± 7.0
42.79 ± 5.9
0.86
AVA VTI (cm2)
Baseline
1.3 ± 0.5
1.4 ± 0.4
1.3 ± 0.5
0.09
Follow-up
0.9 ± 0.3
1.0 ± 0.2
0.8 ± 0.2
<0.001
AV Vmax (m/s)
Baseline
3.1 ± 0.9
3.0 ± 0.9
3.2 ± 0.8
0.03
Follow-up
3.7 ± 0.9
3.4 ± 0.8
4.3 ± 0.7
<0.001
AV Pmax (mmHg)
Baseline
40.9 ± 22.5
39.75 ± 23.3
43.2 ± 20.72
0.14
Follow-up
57.6 ± 25.9
47.4 ± 21.1
76.6 ± 23.3
<0.001
AV Pmean (mmHg)
Baseline
25.0 ± 14.5
24.3 ± 15.1
26.3 ± 13.1
0.20
Follow-up
37.0 ± 17.5
29.8 ± 13.8
50.3 ± 15.9
<0.001
vs. baseline. LVEDD, left ventricular end-diastolic dimension; IVSd, intraventricular septum thickness; LVPWd, left ventricular posterior wall thickness; LVEF, left ventricular ejection fraction; LAD, left atrial dimension; AVA VTI, aortic valve area calculated by the velocity time integral; AV, aortic valve; Pmax, maximal transaortic pressure gradient; Pmean, mean transaortic pressure gradient.
