Research Article
Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis
Table 5
Odds ratio of cardiac comorbidities and risk factors and laboratory parameters at baseline associated with fast Pmean progression.
| | Crude OR (95% CI) | value | Age and sex adjusted OR (95% CI) | value | Age, sex, and LVEF adjusted OR (95% CI) | value |
| Age | 1.005 (0.983–1.028) | 0.644 | — | — | — | — | Male gender | 0.994 (0.656–1.505) | 0.976 | — | — | — | — | LVEF | 1.022 (1.003–1.042) | 0.023 | 1.023 (1.003–1.043) | 0.023 | — | — | BMI ≥ 30 kg/m2 | 1.194 (0.715–1.993) | 0.498 | — | — | — | — | History of smoking | 0.961 (0.627–1.473) | 0.854 | — | — | — | — | Diabetes | 0.707 (0.457–1.094) | 0.119 | — | — | — | — | Coronary heart disease | 0.521 (0.340–0.798) | 0.003 | 0.487 (0.312–0.760) | 0.002 | 0.496 (0.317–0.777) | 0.002 | Myocardial infarction | 0.514 (0.299–0.882) | 0.016 | 0.494 (0.285–0.856) | 0.012 | 0.532 (0.304–0.931) | 0.027 | Hypertension | 0.835 (0.458–1.522) | 0.556 | — | — | — | — | Renal dysfunction | 0.682 (0.449–1.035) | 0.072 | 0.655 (0.428–1.002) | 0.051 | 0.692 (0.450–1.064) | 0.093 | Peripheral artery occlusive disease | 0.620 (0.371–1.036) | 0.068 | 0.609 (0.363–1.022) | 0.061 | 0.610 (0.362–1.027) | 0.063 | Cerebrovascular disease | 1.458 (0.830–2.560) | 0.189 | — | — | — | — | Number of comorbidities | 0.869 (0.761–0.991) | 0.037 | 0.852 (0.741–0.980) | 0.025 | 0.863 (0.750–0.994) | 0.041 | LDL-cholesterol | 1.009 (1.002–1.016) | 0.009 | 1.010 (1.003–1.017) | 0.005 | 1.010 (1.003–1.017) | 0.006 | HDL-cholesterol | 1.015 (1.001–1.029) | 0.034 | 1.015 (1.001–1.029) | 0.042 | 1.014 (1.000–1.028) | 0.051 | HbA1c | 0.969 (0.764–1.229) | 0.793 | — | — | — | — | Hemoglobin | 1.016 (0.985–1.047) | 0.326 | — | — | — | — | C-reactive protein | 0.952 (0.874–1.036) | 0.254 | — | — | — | — | Creatinine | 1.001 (0.799–1.253) | 0.996 | — | — | — | — |
|
|
Pmean, mean transaortic pressure gradient; OR, odds ratio; CI, confidence interval; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HbA1c, hemoglobin A1c.
|