Non-HDL-c/TC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes

Table 1

Baseline characteristics of the study population.

	Non-CAD ()	CAD			value	value
		Low risk ()	Medium risk ()	High risk ()
Age (years)	59.47 ± 8.07	61.27 ± 8.45	63.11 ± 7.62	63.81 ± 8.04	<0.001	0.036
Male (n (%))	39 (32.2%)	48 (38.7%)	71 (60.2%)	82 (63.6%)	<0.001	<0.001
Smoking (n (%))	38 (31.4%)	54 (43.5%)	67 (56.8%)	57 (44.2%)	0.001	0.056
Medical history (n (%))
Hypertension	61 (50.4%)	67 (54.0%)	64 (54.2%)	83 (64.3%)	0.113	0.166
DM	43 (35.5%)	48 (38.7%)	50 (42.4%)	60 (46.5%)	0.324	0.454
Dyslipidemia	57 (47.1%)	70 (56.5%)	64 (54.2%)	78 (60.5%)	0.194	0.603
Laboratory index
CK (U/L)	77 (55, 104)	77 (52, 120)	84 (58, 117)	85 (60, 151)	0.038	0.142
CK-MB (U/L)	10 (8, 12)	12 (9, 15)	12 (9, 16)	13 (9, 18)	<0.001	0.163
hs-CRP (U/L)	1.01 (0.51, 2.10)	1.82 (0.67, 3.20)	1.40 (0.60, 2.98)	2.28 (0.90, 5.15)	0.001	0.057
Cr (mg/dL)	0.67 ± 0.14	0.71 ± 0.16	0.74 ± 0.16	0.81 ± 0.21	<0.001	0.001
HbA1c (%)	6.11 ± 0.74	6.25 ± 0.98	6.48 ± 1.11	6.85 ± 1.46	<0.001	0.001
TC (mg/dL)	4.36 (3.87, 5.22)	4.69 (4.13, 5.32)	4.70 (4.11, 5.28)	4.70 (4.11, 5.30)	0.141	0.724
TG (mg/dL)	1.39 (0.99, 1.92)	1.66 (1.10, 2.27)	1.54 (1.18, 1.97)	1.72 (1.24, 2.43)	0.006	0.099
HDL-c (mg/dL)	1.17 (1.07, 1.38)	1.19 (1.06, 1.40)	1.15 (0.98, 1.30)	1.08 (0.96, 1.27)	0.006	0.005
LDL-c (mg/dL)	2.85 ± 0.85	3.03 ± 0.84	3.01 ± 0.86	3.05 ± 0.92	0.241	0.950
VLDL-c (mg/dL)	0.65 (0.45, 0.89)	0.74 (0.52, 1.05)	0.70 (0.54, 0.92)	0.79 (0.57, 1.11)	0.008	0.079
LVEF (%)	59 (57, 62)	58 (57, 60)	58 (57, 61)	58 (56, 60)	0.109	0.213
Non-HDL-c (mg/dL)	121.78 (104.58, 154.64)	135.70 (108.34, 159.09)	134.92 (113.47, 155.80)	137.63 (119.65, 158.51)	0.049	0.629
Non-HDL-c/TC	0.74 (0.70, 0.77)	0.75 (0.71, 0.78)	0.75 (0.70, 0.78)	0.76 (0.73, 0.79)	0.006	0.016
Adverse events (n (%))	0	7 (5.6%)	16 (13.6%)	32 (24.8%)	NS	<0.001

Values are mean ± SD (standard deviation), median (percentiles 25th–75th), or n (%). value indicates comparison among distinct Gensini risk and non-CAD groups. value indicates comparison among distinct Gensini risk subgroups. and . DM: diabetes mellitus; CK: creatinine kinase; CK-MB: creatinine kinase-MB; hs-CRP: high-sensitivity-C reactive protein; Cr: creatinine; HbA1c: hemoglobin A1c; TC: total cholesterol; TG: total triglyceride; HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; VLDL-c: very-low-density lipoprotein cholesterol; LVEF: left ventricular ejection fraction.