Does Arterial Hypertension Affect Plasma Levels of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Stable Coronary Artery Disease? A Preliminary Study

Table 3

Influence of HT on plasma levels of MMP-2, MMP-9, and TIMP-4.

	CAD + HT + DM−	Control	value	CAD + HT + DM−	CAD + HT − DM−	value
MMP-2 (ng/ml)	133.8 ± 23.4	165.7 ± 19.1	<0.001	133.8 ± 23.4	134.5 ± 23.2	0.93
MMP-9 (ng/ml)	40.9 ± 23.3	47.2 ± 22.3	0.40	40.9 ± 23.3	47.6 ± 29.4	0.46
TIMP-4 (pg/ml)	1573.1 ± 765.6	1153.2 ± 339.9	0.038	1573.1 ± 765.6	1733.0 ± 665.4	0.55

CAD + HT + DM−: group of patients suffering from coronary artery disease and hypertension without diabetes; CAD + HT − DM−: group of patients suffering from coronary artery disease only; MMP-2: matrix metalloproteinase-2; MMP-9: matrix metalloproteinase-9; TIMP-4: tissue inhibitor of metalloproteinases 4. Mean ± SEM. Statistical tests used: Mann–Whitney U test and unpaired t-test.