Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection

Table 2

Specific function of inflammation in MIRI and cardioprotection.

Model	Effector	Target	Activity in MIRI	Reference
Mouse	PI3K	Erk, Akt, GSK3β	Mediates the protective effect by phosphorylation during the IPC trigger phase	[63]
	BAY 60-6583	A2BR	Modulates proinflammatory kinases via the PI3K/Akt pathway in cardiac M2 macrophage	[61]
	TLR5	Unknown	Deficiency of TLR5 aggravates inflammation	[64]
	OPHN1	RhoA, Rac1, Cdc42	Deficiency of OPHN1 increases inflammatory cell migration and cardiomyocyte apoptosis	[66]
	S-Nitrosation	MIF	Stimulates an overall enhanced protective effect	[67]
	Chemerin15	Unknown	Decreases TNFα and IL-6 levels and increases IL-10 levels	[70]
	A20	Unknown	Reduces cardiomyocyte necrosis and apoptosis	[72]
	IKKɑ	Unknown	Causes negative control of macrophage polarization towards M1 phenotype	[57]
	TIPE2	NOD2	Reduces the levels of proinflammatory mediators and cardiac inflammatory cell infiltration	[79]