Cardiology Research and Practice

Research Article

The Effect of Ivabradine on the Human Atrial Myocardial Contractility in an In Vitro Study

Table 1

Summary of the medical profiles and medications of the patients.


Donor Nr.	Group	Age (years)	Gender	BMI (kg/m²)	Diseases	Cardiac function	Surgery	Medications

D 001	Control	63	m	23	CAD, AHT, DM	Normal	Isolated CABG	ASA, bisoprolol, amlodipine

D 002	Control	66	f	26	CAD, AHT, ND, gout	Normal	Isolated CABG	ASA, bisoprolol, furosemide, amlodipine, vitamin D

D 004	Control	64	f	39	CAD, AHT	Normal	Isolated CABG	ASA, clopidogrel, bisoprolol, simvastatin, furosemide, amlodipine

D 005	Control	59	f	24	CAD, AHT, ND	Normal	Isolated CABG	ASA, ramipril

D 006	Control	49	m	31	CAD, AHT, ND, psoriasis	Normal	Isolated CABG	ASA, bisoprolol, simvastatin, amlodipine

D 008	2 μMol	71	m	29	CAD, IBS	Normal	Isolated CABG	ASA, clopidogrel, simvastatin

D 009	2 μMol	60	f	22	CAD, AVS, PAD	Moderately reduced	CABG + AVR	ASA, clopidogrel, furosemide, amlodipine, ramipril

D 010	2 μMol	75	m	33	CAD, DM, ND	Normal	Isolated CABG	ASA, simvastatin, furosemide, metformin

D 011	2 μMol	69	f	28	CAD, AHT	Normal	Isolated CABG	ASA, clopidogrel, bisoprolol, simvastatin

D 012	2 μMol	74	f	36	CAD, DM	Normal	Isolated CABG	ASA, bisoprolol, metformin, amlodipine

D 013	200 nMol	67	m	31	CAD, AHT, DM, ND	Normal	Isolated CABG	clopidogrel, bisoprolol, furosemide, metformin, amlodipine, lorazepam

D 015	200 nMol	62	f	43	CAD, AHT, ND	Normal	Isolated CABG	ASA

D 021	200 nMol	69	m	26	CAD, AHT, ND, PAD	Normal	Isolated CABG	ASA, clopidogrel, simvastatin

D 022	200 nMol	55	m	34	CAD, AVS, MVI, AHT	Normal	CABG + AVR + MVR	ASA, bisoprolol, furosemide, vitamin d

D 023	200 nMol	27	m	24	AVS, ND	Normal	Isolated AVR	ASA

D 027	60 nMol	77	m	25	CAD, AHT, DM, dN	Normal	Isolated CABG	ASA

D 028	60 nMol	77	m	30	CAD, AHT, DM, ND, dN	Normal	Isolated CABG	ASA, metoprolol, ramipril

D 029	60 nMol	59	f	38	CAD, AHT, DM	Normal	Isolated CABG	ASA, bisoprolol, simvastatin, amlodipine

D 030	60 nMol	71	m	27	CAD, AVS, AHT, PAD	Normal	Isolated AVR	ASA, bisoprolol, amlodipine, phenprocoumon

D 031	60 nMol	65	f	34	CAD, MVI, AHT	Normal	Isolated CABG	ASA, bisoprolol, amlodipine

CAD: coronary artery disease, AHT: arterial hypertension, DM: diabetes mellitus, ND: nicotine dependency, IBS: irritable bowel syndrome, AVS: aortic valve stenosis, PAD: peripheral artery disease, MVI: mitral valve insufficiency, dN: diabetic nephropathy, ASA: acetylsalicylic acid. Ivabradine has affected the force of contraction significantly in vitro (). However, force of contraction decreased in both the control group (93.5 ± 4.7%) and the second group (94.1 ± 4.5%, ), force of contraction remained unchanged in the third group (101.0 ± 4.1%, ), and force of contraction increased significantly in the fourth group (108.9 ± 11.6%, ).