Influence of Endogenous Cardiac Glycosides, Digoxin, and Marinobufagenin in the Physiology of Epithelial Cells

Figure 6

Schematic representation of the effects of ECS (marinofugagenin or digoxin). The binding of ECS to Na-K-ATPase promotes the activation of c-Src, which in turn activates ERK1/2, which promotes the activation of rho/ROCK. This in turn increases TER and CIGJ.