Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility

Table 6

Comparison of rs7895833 A > G, rs7069102 C > G, and rs2273773 C > T SNPs with SIRT1 and eNOS protein levels.

	SIRT1 protein (ng/ml)			eNOS protein (pg/ml)
	STEMI group	Control group		STEMI group	Control group
rs7895833 A > G genotype
AA	1.28 ± 1.1	0.71 ± 0.49	0.001	274.23 ± 309.46	503.17 ± 682.03	0.031
AG	1.22 ± 0.6	0.69 ± 0.43	0.002	278.18 ± 323.81	518.99 ± 384.52	0.002
GG	na
rs7069102 C > G genotype
CC	1.46 ± 0.66	0.70 ± 0.40	0.004	262.40 ± 287.08	416.91 ± 131.84	0.153
CG	1.21 ± 0.70	1.22 ± 0.44	0.002	283.14 ± 350.69	428.06 ± 304.50	0.024
GG	1.23 ± 0.72	0.72 ± 0.48	0.014	255.11 ± 193.49	626.22 ± 819.25	0.014
rs2273773 C > T genotype	na
CC
CT
TT

eNOS, endothelial nitric oxide synthase; SIRT1, sirtuin 1; STEMI, ST-elevation myocardial infarction. .