Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility
Table 7
Values of the biochemical parameters in patients carrying the SIRT1 SNPs.
rs33 AA
rs 33AG
rs102 CC
rs 102CG
rs102GG
STEMI ()
CO ()
STEMI ()
CO ()
STEMI
CO
STEMI
CO
STEMI
CO
Triglycerides (mg/dl)
210.5 ± 119.37
157.0 ± 110.44
0.021
185.25 ± 108.68
122.06 ± 148.21
0.032
159.0 ± 112.58
192.0 ± 261.98
0.680
200.83 ± 119.97
136.39 ± 103.74
0.005
201.0 ± 95.13
135.0 ± 96.28
0.016
LDL cholesterol (mg/dl)
111.58 ± 51.85
122.30 ± 35.47
0.228
108.06 ± 38.90
114.06 ± 36.76
0.473
108.31 ± 33.22
115.20 ± 41.48
0.662
108.68 ± 40.54
119.73 ± 36.24
0.154
114.81 ± 65.55
118.86 ± 35.24
0.765
HDL cholesterol (mg/dl)
36.80 ± 9.30
47.34 ± 12.07
<0.001
38.0 ± 10.20
51.75 ± 15.95
<0.001
38.67 ± 9.76
60.0 ± 20.92
0.012
37.56 ± 9.63
48.44 ± 13.59
<0.001
35.84 ± 10.20
46.98 ± 10.53
<0.001
VLDL (mg/dl)
41.23 ± 24.44
31.83 ± 22.03
0.044
36.45 ± 21.74
28.07 ± 36.31
0.183
41.23 ± 24.44
31.83 ± 22.03
0.357
39.52 ± 24.36
27.30 ± 20.78
0.008
40.20 ± 19.03
27.59 ± 19.26
0.021
TG/HDL
6.35 ± 4.16
3.69 ± 3.22
0.001
5.99 ± 6.20
2.69 ± 3.47
0.002
4.70 ± 3.81
3.95 ± 6.13
0.352
6.34 ± 5.73
3.29 ± 3.31
0.001
6.34 ± 4.0
3.07 ± 2.24
0.003
Fasting blood glucose (mg/dl)
128.82 ± 74.84
74.38 ± 45.63
0.058
144.26 ± 100.78
92.97 ± 9.47
0.001
132.08 ± 85.50
85.50 ± 13.57
0.145
138.50 ± 96.40
96.61 ± 17.07
0.007
133.03 ± 59.29
107.46 ± 51.98
0.092
Uric acid (mg/dl)
5.25 ± 1.18
4.45 ± 1.23
0.003
5.38 ± 1.38
4.38 ± 1.30
0.002
5.45 ± 1.05
4.63 ± 1.44
0.148
5.35 ± 1.29
4.47 ± 1.26
0.002
5.12 ± 1.44
4.31 ± 1.22
0.057
BMI
28.65 ± 3.27
25.0 ± 3.90
<0.001
28.82 ± 4.77
24.33 ± 3.96
<0.001
29.23 ± 6.71
24.32 ± 5.31
0.071
28.72 ± 3.69
25.15 ± 3.60
<0.001
28.3 ± 3.48
24.25 ± 3.95
<0.001
n, number of individuals. Statistical evaluation by Student’s t-test. The results are shown as mean ± standard deviation (SD). HDL, high-density lipoprotein; LDL, low-density lipoprotein; VLDL, very low-density lipoprotein; BMI, body mass index. .
