Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the five studies included in this meta-analysis.

First author and year	Location	Period of enrollment	Study design	Total patients, N	Cancer type	Incident cases of AF, N (%)	AF type	Criterion for AF diagnosis	Covariates in adjusted model	Follow-up (year)	Quality score
Guzzetti 2008 [8]	Italy	1987–2004	Case-control	1868	Colorectal and breast cancer	49 (2.6)	New-onset AF	Routine presurgery ECG	Age, sex	NA	8
Erichsen 2012 [7]	Denmark	1999–2006	Case-control	311593	Colorectal cancer	NA	AF/Flutter	According to the ICD	Age, sex, country	NA	8
Jakobsen 2015 [9]	Denmark	2000–2012	Prospective cohort	5539824	All types of cancer	NA	New-onset AF	NA	Age, sex	12	7
Nouraie 2015 [6]	USA	2000–2012	Retrospective cohort	1258	Colorectal cancer	93 (7.4)	New-onset AF	According to the ICD	Age, HTN, HF, DM, alcohol, tobacco	NA	8
Conen 2016 [10]	USA	1993–2013	Prospective cohort	34691	All types of cancer	824 (2.3)	New-onset AF	Electrocardiographic AF documentation or a medical report that documented a diagnosis of AF	Age, EDU, race, height, BMI, HTN, DM, smoking, HC, alcohol, physical activity, CHF, MI, stroke	19.1	9

AF = atrial fibrillation; BMI = body mass index; CHF = congestive heart failure; CRP = C-reactive protein; DM = diabetes mellitus; ECG = electrocardiography; EDU = educational lever; HC = hypercholesterolemia; HDL-c = high-density lipoprotein cholesterol; HF = heart failure; HTN = hypertension; ICD = International Classification of Diseases; LVH = left ventricular hypertrophy; MI = myocardial infarction; NA = not applicable; SBP = systolic blood pressure; TC = total cholesterol.