Research Article

Combination of Left Ventricular End-Diastolic Diameter and QRS Duration Strongly Predicts Good Response to and Prognosis of Cardiac Resynchronization Therapy

Table 1

Baseline characteristics.

CharacteristicsTotal population ()Responders ()Nonresponders () value

Age (years)61.22 ± 9.5461.65 ± 10.3960.33 ± 7.550.473
Sex (female)31 (30.7%)19 (27.9%)12 (36.4%)0.389
BNP (ng/L)401 (213–1185)321 (181.3–1129)685 (325.5–1230)0.537
NYHA class
 II21 (20.8%)15 (22.1%)6 (18.2%)0.652
 III60 (59.4%)40 (58.8%)20 (60.6%)0.864
 IV20 (19.8%)13 (19.1%)7 (21.2%)0.804
HF duration (months)48 (12–72)30 (12–72)60 (30–96)0.192
Hypertension, n (%)21 (20.8%)15 (22.1%)6 (18.2%)0.652
CRD, n (%)18 (17.8%)11 (16.2%)7 (21.2%)0.535
ICM, n (%)17 (16.8%)12 (17.6%)5 (15.2%)0.756
LVEF (%)29.40 ± 4.4229.56 ± 4.1029.08 ± 5.060.609
LAD (mm)44.39 ± 5.4843.41 ± 5.2046.43 ± 5.580.009
LVEDD (mm)70.06 ± 7.8468.68 ± 7.3872.91 ± 8.120.010
MR (cm2)7.2 (4.5–10.4)7.2 (4.5–10.4)7.5 (4.4–10.4)0.278
QRS duration (ms)165.30 ± 21.33171.20 ± 21.56153.30 ± 15.07< 0.001
LBBB, n (%)62 (61.4%)47 (69.1%)15 (45.5%)0.022
Mean follow-up time (months)23.76 ± 14.4823.60 ± 14.8324.09 ± 13.950.875

Values are mean ± SD, median (range) or n (%). BNP: brain natriuretic peptide; NYHA: New York Heart Association; HF: heart failure; CRD: chronic renal dysfunction; ICM: ischemic cardiomyopathy; LVEF: left ventricular ejection fraction; LAD: left atrial dimension; LVEDD: left ventricular end-diastolic dimension; MR: mitral regurgitation; LBBB: left bundle branch block.